Evidence map›Paper›PMID 35062283›Full record

ArticleViruses2022

SARS-CoV-2 T Cell Responses Elicited by COVID-19 Vaccines or Infection Are Expected to Remain Robust against Omicron.

Syed Faraz Ahmed, Ahmed Abdul Quadeer, Matthew R McKay

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 59 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 4 pooled it
8.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 4 syntheses or guidelines pooled it, 88 citations in OpenAlex.

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  4. Effectiveness and Durability of COVID-19 Vaccination in 9447 Patients With IBD: A Systematic Review and Meta-Analysis.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2022
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 2 countries.

Syed Faraz AhmedDepartment of Electronic and Computer Engineering, The Hong Kong University of Science and Technology, Hong Kong SAR, China.ORCID 0000-0002-6086-0307
Ahmed Abdul QuadeerDepartment of Electronic and Computer Engineering, The Hong Kong University of Science and Technology, Hong Kong SAR, China.ORCID 0000-0002-5295-9067
Matthew R McKayDepartment of Electronic and Computer Engineering, The Hong Kong University of Science and Technology, Hong Kong SAR, China.ORCID 0000-0002-8086-2545
Hong Kong University of Science and Technology · HKThe University of Melbourne · AU

Funding

Hong Kong Research Grants Council, University Grants Committee 16213121
6 · The paper itself

Abstract

Omicron, the most recent SARS-CoV-2 variant of concern (VOC), harbours multiple mutations in the spike protein that were not observed in previous VOCs. Initial studies suggest Omicron to substantially reduce the neutralizing capability of antibodies induced from vaccines and previous infection. However, its effect on T cell responses remains to be determined. Here, we assess the effect of Omicron mutations on known T cell epitopes and report data suggesting T cell responses to remain broadly robust against this new variant.

Indexed as

COVID-19COVID-19 VaccinesEpitopes, T-LymphocyteHumansMutationSARS-CoV-2Spike Glycoprotein, CoronavirusT-LymphocytesViral ProteinsCOVID-19 VaccinesEpitopes, T-LymphocyteSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2Viral ProteinsCOVID-19deletionsinsertionsmutationsOmicronpeptide-HLA bindingSARS-CoV-2T cell epitopesvariants

Identifiers

PMID35062283
PMCPMC8781795
OpenAlexW4205942182

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.