Evidence map›Paper›PMID 35062273›Full record

ArticleViruses2021

Discovery of Highly Potent Fusion Inhibitors with Potential Pan-Coronavirus Activity That Effectively Inhibit Major COVID-19 Variants of Concern (VOCs) in Pseudovirus-Based Assays.

Francesca Curreli, Shahad Ahmed, Sofia M B Victor, Aleksandra Drelich, Siva S Panda, Andrea Altieri, Alexander V Kurkin, Chien-Te K Tseng, Christopher D Hillyer, Asim K Debnath

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 10 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 4 institutions in 2 countries.

Francesca CurreliLaboratory of Molecular Modeling & Drug Design, New York Blood Center, Lindsley F. Kimball Research Institute, New York, NY 10065, USA.
Shahad AhmedLaboratory of Molecular Modeling & Drug Design, New York Blood Center, Lindsley F. Kimball Research Institute, New York, NY 10065, USA.
Sofia M B VictorLaboratory of Molecular Modeling & Drug Design, New York Blood Center, Lindsley F. Kimball Research Institute, New York, NY 10065, USA.
Aleksandra DrelichDepartment of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, TX 77555, USA.
Siva S PandaDepartment of Chemistry & Physics, Augusta University, Augusta, GA 30912, USA.ORCID 0000-0003-3668-104X
Andrea AltieriEDASA Scientific, Scientific Campus, Moscow State University, Leninskie Gory Bld. 75, 77-101b, 119992 Moscow, Russia.ORCID 0000-0002-9815-9866
Alexander V KurkinEDASA Scientific, Scientific Campus, Moscow State University, Leninskie Gory Bld. 75, 77-101b, 119992 Moscow, Russia.
Chien-Te K TsengDepartment of Microbiology and Immunology, The University of Texas Medical Branch, Galveston, TX 77555, USA.
Christopher D HillyerNew York Blood Center, New York, NY 10065, USA.
Asim K DebnathLaboratory of Molecular Modeling & Drug Design, New York Blood Center, Lindsley F. Kimball Research Institute, New York, NY 10065, USA.ORCID 0000-0003-2761-0506
New York Blood Center · USLomonosov Moscow State University · RUThe University of Texas Medical Branch at Galveston · USAugusta University · US

Funding

New York Blood Center Intramural
6 · The paper itself

Abstract

We report the discovery of several highly potent small molecules with low-nM potency against severe acute respiratory syndrome coronavirus (SARS-CoV; lowest half-maximal inhibitory concentration (IC

Indexed as

AnimalsAntiviral AgentsBiological AvailabilityCell LineCell SurvivalCoronavirusHIV Fusion InhibitorsHumansProtein BindingRatsSARS-CoV-2Small Molecule LibrariesSpike Glycoprotein, CoronavirusVirus InternalizationAntiviral AgentsHIV Fusion InhibitorsSmall Molecule LibrariesSpike Glycoprotein, Coronavirusspike protein, SARS-CoV-2COVID-19fusion inhibitorMERS-CoVmiddle east respiratory syndrome (MERS)pan-coronavirusSARS-CoVSARS-CoV-2severe acute respiratory syndrome (SARS)

Identifiers

PMID35062273
PMCPMC8780828
OpenAlexW4205495208

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.