Evidence map›Paper›PMID 35062217›Full record

ArticleViruses2021

Adenovirus Co-Opts Neutrophilic Inflammation to Enhance Transduction of Epithelial Cells.

James M Readler, Meghan R Burke, Priyanka Sharma, Katherine J D A Excoffon, Abimbola O Kolawole

Open access · goldAbstract read
In one paragraph

Article in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

James M ReadlerDepartment of Biological Sciences, Wright State University, Dayton, OH 45435, USA.
Meghan R BurkeDepartment of Biological Sciences, Wright State University, Dayton, OH 45435, USA.
Priyanka SharmaDepartment of Biological Sciences, Wright State University, Dayton, OH 45435, USA.
Katherine J D A ExcoffonDepartment of Biological Sciences, Wright State University, Dayton, OH 45435, USA.ORCID 0000-0003-3945-0298
Abimbola O KolawoleDepartment of Biological Sciences, Wright State University, Dayton, OH 45435, USA.ORCID 0000-0001-8520-865X
Wright State University · US

Funding

Prevention of adenovirus pathogenesis through downregulation of the apical adenovirus receptorR01AI127816 · NIAID · WRIGHT STATE UNIVERSITY · PI KOLAWOLE, ABIMBOLA OLAYINKA · 2017 to 2021
$1.9M
NIAID NIH HHS R01 AI127816
6 · The paper itself

Abstract

Human adenoviruses (HAdV) cause a variety of infections in human hosts, from self-limited upper respiratory tract infections in otherwise healthy people to fulminant pneumonia and death in immunocompromised patients. Many HAdV enter polarized epithelial cells by using the primary receptor, the Coxsackievirus and adenovirus receptor (CAR). Recently published data demonstrate that a potent neutrophil (PMN) chemoattractant, interleukin-8 (IL-8), stimulates airway epithelial cells to increase expression of the apical isoform of CAR (CAR

Indexed as

Virus InternalizationAdenoviruses, HumanAnimalsAutophagyCoxsackie and Adenovirus Receptor-Like Membrane ProteinCytochalasin BDogsEndocytosisEpithelial CellsHumansImmunity, InnateLeukocyte ElastaseMacrolidesMadin Darby Canine Kidney CellsNeutrophilsReceptors, Virusadenovirus receptorbafilomycin ACoxsackie and Adenovirus Receptor-Like Membrane ProteinCytochalasin BLeukocyte ElastaseMacrolidesReceptors, Virusadenovirusautophagyentryhuman neutrophil elastaseMDCK epithelial cellsneutrophil

Identifiers

PMID35062217
PMCPMC8781108
OpenAlexW4200452583

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.