ArticleViruses2021
Modeling SARS-CoV-2 Infection in Mice Using Lentiviral hACE2 Vectors Infers Two Modes of Immune Responses to SARS-CoV-2 Infection.
Chaja Katzman, Tomer Israely, Sharon Melamed, Boaz Politi, Assa Sittner, Yfat Yahalom-Ronen, Shay Weiss, Reem Abu Rass, Rachel Zamostiano, Eran Bacharach and 3 more
Open access · goldAbstract read
In one paragraphArticle in Viruses, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
13 authors at 3 institutions in 1 country.
Chaja KatzmanDepartment of Biochemistry and Molecular Biology, Institute for Medical Research Israel-Canada, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel.
Tomer IsraelyDepartment of Infectious Diseases, Israel Institute for Biological Research, P.O. Box 19, Ness Ziona 7410001, Israel.
Sharon MelamedDepartment of Infectious Diseases, Israel Institute for Biological Research, P.O. Box 19, Ness Ziona 7410001, Israel.
Boaz PolitiDepartment of Infectious Diseases, Israel Institute for Biological Research, P.O. Box 19, Ness Ziona 7410001, Israel.
Assa SittnerDepartment of Infectious Diseases, Israel Institute for Biological Research, P.O. Box 19, Ness Ziona 7410001, Israel.ORCID 0000-0002-1633-8191 Yfat Yahalom-RonenDepartment of Infectious Diseases, Israel Institute for Biological Research, P.O. Box 19, Ness Ziona 7410001, Israel.
Shay WeissDepartment of Infectious Diseases, Israel Institute for Biological Research, P.O. Box 19, Ness Ziona 7410001, Israel.
Reem Abu RassFaculty of Life Sciences, The Shmunis School of Biomedicine and Cancer Research, Tel Aviv University, Tel-Aviv 69978, Israel.ORCID 0000-0001-9614-3847 Rachel ZamostianoFaculty of Life Sciences, The Shmunis School of Biomedicine and Cancer Research, Tel Aviv University, Tel-Aviv 69978, Israel.
Eran BacharachFaculty of Life Sciences, The Shmunis School of Biomedicine and Cancer Research, Tel Aviv University, Tel-Aviv 69978, Israel.ORCID 0000-0001-8341-2833 Marcelo EhrlichFaculty of Life Sciences, The Shmunis School of Biomedicine and Cancer Research, Tel Aviv University, Tel-Aviv 69978, Israel.ORCID 0000-0002-2352-1808 Nir ParanDepartment of Infectious Diseases, Israel Institute for Biological Research, P.O. Box 19, Ness Ziona 7410001, Israel.
Lior NissimDepartment of Biochemistry and Molecular Biology, Institute for Medical Research Israel-Canada, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 91120, Israel.ORCID 0000-0001-6495-4741 Israel Institute for Biological Research · ILTel Aviv University · ILHebrew University of Jerusalem · IL
Funding
The Milner Foundation 3175005849
6 · The paper itselfAbstract
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) caused a severe global pandemic. Mice models are essential to investigate infection pathology, antiviral drugs, and vaccine development. However, wild-type mice lack the human angiotensin-converting enzyme 2 (hACE2) that mediates SARS-CoV-2 entry into human cells and consequently are not susceptible to SARS-CoV-2 infection. hACE2 transgenic mice could provide an efficient COVID-19 model, but are not always readily available, and practically restricted to specific strains. Therefore, there is a dearth of additional mouse models for SARS-CoV-2 infection. We applied lentiviral vectors to generate hACE2 expression in interferon receptor knock-out (IFNAR1
Indexed as
Disease Models, AnimalAngiotensin-Converting Enzyme 2AnimalsCell LineCOVID-19HumansImmunityLentivirusLungMiceMice, TransgenicReceptor, Interferon alpha-betaSARS-CoV-2Transduction, GeneticVirus ReplicationACE2 protein, humanAngiotensin-Converting Enzyme 2Ifnar1 protein, mouseReceptor, Interferon alpha-betaCOVID-19hACE2immune responselentivirusmouse modelSARS-CoV-2
Identifiers
PMID35062215
PMCPMC8778683
OpenAlexW4200381749
What OpenQuestion holds
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LicenceCC BY
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