ArticleClinical and translational medicine2022
An atlas of dynamic peripheral blood mononuclear cell landscapes in human perioperative anaesthesia/surgery.
Article in Clinical and translational medicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 12 citations in OpenAlex.
- Immune and metabolic remodeling following bariatric surgery: Implications for targeted immunotherapy (Review).International journal of molecular medicine · 2026Review
- Setting the stage for cardiomyopathy gene editing trials: a systematic review of isogenic pair use in human induced pluripotent stem cell-derived cardiomyocyte research.European heart journal open · 2026Article
- Surgery/anesthesia may cause monocytes to promote tumor development.Molecular medicine (Cambridge, Mass.) · 2025Article
- Landscape of the Peripheral Immune Response Induced by Intraoperative Radiotherapy Combined with Surgery in Early Breast Cancer Patients.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- General anesthesia induces acute cell-free DNA methylation changes in peripheral blood.Journal of thoracic disease · 2024Article
- Macrophages-derived high-mobility group box-1 protein induces endothelial progenitor cells pyroptosis.iScience · 2024Article
- Dynamic immune recovery process after liver transplantation revealed by single-cell multi-omics analysis.Innovation (Cambridge (Mass.)) · 2024Article
- An atlas of dynamic peripheral blood mononuclear cell landscapes in human perioperative anaesthesia/surgery.Clinical and translational medicine · 2022Article
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundThe number of patients receiving anaesthesia is increasing, but the impact of general anaesthesia on the patient's immune system remains unclear. The aim of the present study is to investigate dynamics of systemic immune cell responses to anaesthesia during perioperative period at a single-cell solution.
methodsThe peripheral blood mononuclear cells (PBMCs) and clinical phenomes were harvested and recorded 1 day before anaesthesia and operation, just after anaesthesia (0 h), and 24 and 48 h after anaesthesia. Single-cell sequencing of PBMCs was performed with 10× genomics. Subsequently, data analysis was performed with R packages: Seurat, clusterProfiler and CellPhoneDB.
resultsWe found that the cluster of CD56
conclusionWe initially reported the roles of perioperative anaesthesia/surgery in temporal phenomes of circulating immune cells at a single-cell solution. Thus, the protection against immune cell changes would benefit the recovery from anaesthesia/surgery.
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Registered trials
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