ReviewArtificial organs2022
Narrative review of the systemic inflammatory reaction to cardiac surgery and cardiopulmonary bypass.
Review in Artificial organs, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06539234 (Angiotensin II Stress Test. Renin Kinetics During Treatment of Vasoplegic Shock With Angiotensin II in Relation to Hemodynamic Response to Treatment With Angiotensin II.), which is not on this map. Cited by 85 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Angiotensin II Stress Test. Renin Kinetics During Treatment of Vasoplegic Shock With Angiotensin II in Relation to Hemodynamic Response to Treatment With Angiotensin II.
Who cites it
85 citing papers in PubMed, 4 syntheses or guidelines pooled it, 97 citations in OpenAlex.
- National Heart Center Perfusion Guidelines.Saudi medical journal · 2026Guideline
- Does Cardiopulmonary Bypass Influence Outcomes in Stage 2 Palliation?Sultan Qaboos University medical journal · 2026Pooled it
- The role of hemoadsorption in cardiac surgery - a systematic review.BMC cardiovascular disorders · 2024Pooled it
- Effects of interventions targeting the systemic inflammatory response to cardiac surgery on clinical outcomes in adults.The Cochrane database of systematic reviews · 2023Pooled it
- The combined use of HA380 hemoperfusion in cardiopulmonary bypass alleviates postoperative inflammatory response and organ dysfunction following cardiac surgery.Journal of cardiothoracic surgery · 2026Trial
- Trial
- Perioperative hyperbaric oxygen therapy: mechanisms, evidence, and clinical application.Medical gas research · 2027Review
- Prolonged Mechanical Ventilation and In-Hospital Mortality Following Open-Heart Surgery: A Retrospective Cohort Study.Cardiology research · 2026Article
- Review
- COVID-19 mRNA Vaccines as Antigen-Agnostic Immunomodulators: A Repurposing Perspective.Medical sciences (Basel, Switzerland) · 2026Review
- Prognostic Value of Dynamic Hematologic Immune-Inflammatory Indices in Patients Undergoing Isolated Coronary Artery Bypass Grafting.Journal of clinical medicine · 2026Article
- Cytokine trajectories after cardiopulmonary bypass in children: a systematic review and quantitative synthesis.International journal of cardiology. Congenital heart disease · 2026Article
- The immunomodulatory effect of continuous ultrafiltration during pediatric cardiac surgery.Perfusion · 2026Observational
- Association of Previous COVID-19 Infection and Preoperative Haemoglobin with Transfusion Burden and Early Postoperative Outcomes Following Cardiac Surgery with Cardiopulmonary Bypass.Journal of clinical medicine · 2026Article
- Comparable lung injury with and without distal perfusion during aortic arch procedure in piglets.Pediatric research · 2026Article
- Predictors of Prolonged ICU Stay After Isolated CABG: The Role of MiECC.Medicina (Kaunas, Lithuania) · 2026Article
- Mechanistic success and clinical neutrality: lessons from the OXICARD trial.Journal of thoracic disease · 2026Article
- TM and t-PAIC may be possible biomarkers to predict postoperative infection after cardiac surgery with cardiopulmonary bypass.Journal of cardiothoracic surgery · 2026Observational
- Cancer as a Hidden Catalyst: Rethinking Postoperative Atrial Fibrillation After Cardiac Surgery.Journal of clinical medicine · 2026Review
- Prophylactic Methylprednisolone in Neonatal On-Pump Cardiac Surgery.Reviews in cardiovascular medicine · 2026Article
25 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundData from large cardiac surgery registries have been depicting a downward trend of mortality and morbidities in the last 20 years. However, despite decades of medical evolution, cardiac surgery and cardiopulmonary bypass still provoke a systemic inflammatory response, which occasionally leads to worsened outcome. This article seeks to outline the mechanism of the phenomenon.
methodsA thorough review of the literature has been performed. Criteria for considering studies for this non-systematic review were as follows: observational and interventional studies investigating the systemic inflammatory response to cardiac surgery, experimental studies describing relevant molecular mechanisms, and essential review studies pertinent to the topic.
resultsThe intrinsic variability of the inflammatory response to cardiac surgery, together with its heterogenous perception among clinicians, as well as the arduousness to early discriminate high-responder patients from those who will not develop a clinically relevant reaction, concurred to hitherto unconclusive randomized controlled trials. Furthermore, peremptory knowledge about the pathophysiology of maladaptive inflammation following heart surgery is still lacking.
conclusionsSystemic inflammation following cardiac surgery is a frequent entity that occasionally becomes clinically relevant. Specific genomic differences, age, and other preoperative factors influence the magnitude of the response, which elements display extreme redundancy and pleiotropism that the target of a single pathway cannot represent a silver bullet.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.