ArticleBlood2022
Early intestinal microbial features are associated with CD4 T-cell recovery after allogeneic hematopoietic transplant.
Article in Blood, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 38 citations in OpenAlex.
- Randomized Double-Blind Phase II Trial of Fecal Microbiota Transplantation Versus Placebo in Allogeneic Hematopoietic Cell Transplantation and AML.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2023Trial
- The gut microbiome in solid-organ and haematopoietic-stem-cell transplantation.Nature reviews. Microbiology · 2026Review
- The intestinal microbiota as a key modulator of acute graft-versus-host disease.Nature reviews. Cancer · 2026Review
- Microbiome, GvHD, and immune reconstitution in allogeneic hematopoietic cell transplantation.Bone marrow transplantation · 2026Review
- Advances in Understanding the Impact of Human Gut Microbiota on Chemotherapy-Induced Neutropenia.Biomedicines · 2025Review
- Intestinal Microbiome Modulation of Therapeutic Efficacy of Cancer Immunotherapy.Gastroenterology clinics of North America · 2025Review
- Correlating High-dimensional longitudinal microbial features with time-varying outcomes with FLORAL.bioRxiv : the preprint server for biology · 2025Article
- Advancing therapeutic strategies for graft-versus-host disease by targeting gut microbiome dynamics in allogeneic hematopoietic stem cell transplantation: current evidence and future directions.Molecular medicine (Cambridge, Mass.) · 2025Review
- Scalable log-ratio lasso regression for enhanced microbial feature selection with FLORAL.Cell reports methods · 2024Article
- Review
- Blood and guts: how the intestinal microbiome shapes hematopoiesis and treatment of hematologic disease.Blood · 2024Review
- Altered microbial bile acid metabolism exacerbates T cell-driven inflammation during graft-versus-host disease.Nature microbiology · 2024Article
- Investigating the effects of radiation, T cell depletion, and bone marrow transplantation on murine gut microbiota.Frontiers in microbiology · 2024Article
- Enhanced Feature Selection for Microbiome Data using FLORAL: Scalable Log-ratio Lasso Regression.bioRxiv : the preprint server for biology · 2023Article
- Fecal Transplantation in Hematopoietic Transplantation.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2023Article
- Article
- Conditioning Regimens are Associated with Distinct Patterns of Microbiota Injury in Allogeneic Hematopoietic Cell Transplantation.Clinical cancer research : an official journal of the American Association for Cancer Research · 2023Article
- Gut microbiome homeostasis and the future of probiotics in cancer immunotherapy.Frontiers in immunology · 2023Review
- Host-microbe interactions and outcomes in multiple myeloma and hematopoietic stem cell transplantation.Cancer metastasis reviews · 2022Review
- The contribution of the intestinal microbiome to immune recovery after HCT.Frontiers in immunology · 2022Review
Corrections and comments
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Authors and funding
27 authors at 2 institutions in 2 countries.
Funding
Abstract
Low intestinal microbial diversity is associated with poor outcomes after allogeneic hematopoietic cell transplantation (HCT). Using 16S rRNA sequencing of 2067 stool samples and flow cytometry data from 2370 peripheral blood samples drawn from 894 patients who underwent allogeneic HCT, we have linked features of the early post-HCT microbiome with subsequent immune cell recovery. We examined lymphocyte recovery and microbiota features in recipients of both unmodified and CD34-selected allografts. We observed that fecal microbial diversity was an independent predictor of CD4 T-cell count 3 months after HCT in recipients of a CD34-selected allograft, who are dependent on de novo lymphopoiesis for their immune recovery. In multivariate models using clinical factors and microbiota features, we consistently observed that increased fecal relative abundance of genus Staphylococcus during the early posttransplant period was associated with worse CD4 T-cell recovery. Our observations suggest that the intestinal bacteria, or the factors they produce, can affect early lymphopoiesis and the homeostasis of allograft-derived T cells after transplantation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.