ArticleAge and ageing2022
Association between kidney function and incidence of dementia: 10-year follow-up of the Whitehall II cohort study.
Article in Age and ageing, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 2 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
36 citing papers in PubMed, 2 syntheses or guidelines pooled it, 35 citations in OpenAlex.
- Population attributable fractions of a wide range of peripheral diseases for the burden of dementia.Nature human behaviour · 2026Pooled it
- Association of acute kidney injury with the risk of cognitive impairment or dementia: a systematic review and meta-analysis.Renal failure · 2023Pooled it
- A National Big Data Analysis on Alzheimer's and Other Dementias in Türkiye.Journal of aging research · 2026Article
- Hypergraph clustering for analyzing chronic disease patterns in mild cognitive impairment reversion and progression.Scientific reports · 2025Article
- Combined Influence of Depressive Symptoms and Estimated Glomerular Filtration Rate on Cognition Decline in US Adults.Brain and behavior · 2025Article
- Cognitive impairment in chronic kidney disease: mechanisms, clinical manifestations, and management strategies.Metabolic brain disease · 2025Review
- Cognitive Impairment and Physical Dysfunction Associated With Unplanned Dialysis Initiation.Kidney international reports · 2025Article
- Association between baseline cardio-kidney-metabolic syndrome, its transition and cognitive impairment: result from CHARLS study.Diabetology & metabolic syndrome · 2025Article
- Uremic Toxins, CKD, and Cognitive Dysfunction.Journal of the American Society of Nephrology : JASN · 2025Review
- Heterogeneous treatment effects of GLP-1RAs and SGLT2is on risk of Alzheimer's disease and related dementia in patients with type 2 diabetes: Insights from a real-world target trial emulation.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Kidney Function and Incident Stroke and Dementia Using an Updated Estimated Glomerular Filtration Rate Equation Without Race: The Multi-Ethnic Study of Atherosclerosis.Kidney medicine · 2025Article
- 2025 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2025Review
- Article
- Establishing a machine learning dementia progression prediction model with multiple integrated data.BMC medical research methodology · 2024Article
- Assessing Risk Factors for Cognitive Decline Using Electronic Health Record Data: A Scoping Review.Research square · 2024Article
- Impact of Dementia in Colorectal Cancer Patients: United States Population-Based Cohort Study.The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi · 2024Article
- Cognitive decline related to chronic kidney disease as an exclusion factor from kidney transplantation: results from an international survey.Clinical kidney journal · 2024Article
- 2024 Heart Disease and Stroke Statistics: A Report of US and Global Data From the American Heart Association.Circulation · 2024Review
- Association of Kidney Function With Dementia and Structural Brain Differences: A Large Population-Based Cohort Study.The journals of gerontology. Series A, Biological sciences and medical sciences · 2024Article
- Navigating Sex-Specific Disease Dynamics in Incident Dementia.Proceedings. IEEE International Conference on Bioinformatics and Biomedicine · 2023Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
Abstract
backgroundCognitive dysfunction is common in haemodialysis patients but whether poor kidney function in the general population is also associated with higher risk of dementia remains unclear.
objectiveTo examine the association of kidney function with incident dementia in community dwelling older adults.
designWhitehall II prospective study.
settingPopulation-based study on 6,050 adults, mean age 65.8 in 2007-2009.
methodsPoor kidney function, defined as estimated Glomerular Filtration Rate (eGFR) <60 ml/min/1.73 m2 in 2007-2009, and adverse change in eGFR was defined as decrease ≥4 ml/min/1.73 m2 between 2007-2009 and 2012-2013.Incident dementia was ascertained through linkage to electronic health records, and Cox regression was used to examine associations with dementia.
resultsA total of 306 cases of dementia were recorded over a mean follow-up of 10 years. Baseline eGFR <60 was associated with a hazard ratio (HR) for dementia of 1.37 (95% CI 1.02, 1.85) in analysis adjusted for sociodemographic factors, hypertension, obesity, stroke, diabetes and cardiovascular disease/medication. Removing stroke cases at baseline and censoring them over the follow-up yielded an HR of 1.42 (95% CI 1.00, 2.00) for the association between CKD and dementia. Decline of eGFR ≥4 between 2007-2009 and 2012-2013 was associated with incidence of dementia over a 6.3 year mean follow-up (HR: 1.37; 95% CI 1.02, 1.85), with somewhat stronger associations when analyses were restricted to those with eGFR ≥60 in 2007-2009 (1.56; 95% CI: 1.12, 2.19).
conclusionPoor and declining kidney function in older adults is associated with a higher risk of dementia that is not attributable to stroke and persists after accounting for major cardiometabolic conditions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.