SynthesisPloS one2022
"Sarcopenia and risk of osteoporosis, falls and bone fractures in patients with chronic kidney disease: A systematic review".
Synthesis in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07193056 (Chronic Kidney Disease -Mineral and Bone Disorder, The CPH-MBD Cohort), which is not on this map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Chronic Kidney Disease -Mineral and Bone Disorder, The CPH-MBD Cohort
Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- High prevalence of sarcopenia, osteoporosis and osteosarcopenia in patients with chronic kidney disease compared with healthy controls.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2026Article
- Psoas muscle volume as a diagnostic indicator for sarcopenia: criteria development and comparison with traditional diagnostic approaches.Aging clinical and experimental research · 2026Article
- Association between creatinine clearance and lumbar bone mineral density in Chinese patients with osteoporotic fractures: a retrospective cross-sectional study.Frontiers in endocrinology · 2026Article
- Knowledge, attitudes, and practices of patients with chronic kidney disease toward osteosarcopenia.Frontiers in endocrinology · 2026Article
- Article
- Treatment of Osteoporosis in Patients with Chronic Kidney Disease.Current osteoporosis reports · 2025Review
- Sarcopenia associated with increased risk of comorbidities among individuals with chronic kidney disease: insights from a prospective cohort.Frontiers in public health · 2025Article
- Causality between Sarcopenia and Depression: A Bidirectional Mendelian Randomization Study.Actas espanolas de psiquiatria · 2024Article
- Crosstalk between muscle and bone.Journal of bone and mineral metabolism · 2024Review
- Association between sarcopenia grade and fall history among older adults in West China: A retrospective study.BMJ open · 2024Article
- Comparison of the utility of SARC-F, SARC-CalF, and calf circumference as screening tools for sarcopenia in patients with osteoporosis.PloS one · 2024Article
- Management of fracture risk in CKD-traditional and novel approaches.Clinical kidney journal · 2023Review
- Consensus document on palliative care in cardiorenal patients.Frontiers in cardiovascular medicine · 2023Review
- Osteoporosis Risk in Hemodialysis Patients: The Roles of Gender, Comorbidities, Biochemical Parameters, Health and Diet Literacy.Nutrients · 2022Article
- Association of Micronutrients and Handgrip Strength in Korean Older Population: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2022Article
- Relationship between Coffee Consumption and Osteoporosis Risk Determined by the ESR1 Polymorphism rs2982573.The journal of nutrition, health & aging · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic kidney disease [CKD] has been suggested to increase the risk of osteoporosis, sarcopenia, falls, and fractures. The aim of this systematic review was to explore the occurrence of osteoporosis, falls, and fractures in patients with sarcopenia and CKD, and to explore the possible association between sarcopenia and osteoporosis, falls, and fractures in patients with CKD.
methodsThis systematic review was conducted according to the PRISMA guideline. The protocol was registered at PROSPERO. The systematic literature search was conducted in Pubmed [1966 to present] and EMBASE [1974 to present] on December 4, 2020. We searched for articles on CKD and sarcopenia, and then we selected them with outcomes such as osteoporosis, falls, and bone fractures. The risk of bias was assessed with the Newcastle-Ottawa Scale.
resultsFive studies were eligible and included. No studies reported the occurrence of osteoporosis, falls, and bone fractures in patients with CKD and sarcopenia. Sarcopenia had a significant association with low bone mineral density [BMD] and osteoporosis in patients with CKD. The risk of bias assessed with the Newcastle-Ottawa Scale varied from 3-7 stars [median of 7]. Due to the included studies' heterogeneity, a meta-analysis could not be conducted.
conclusionThe occurrence of osteoporosis, falls, and bone fractures in patients with sarcopenia and CKD could not be assessed from the included studies, but an association between sarcopenia and decreased BMD/osteoporosis in patients with CKD was found. The potential mechanistic link between sarcopenia and osteoporosis in CKD needs to be investigated in future studies.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.