Evidence map›Paper›PMID 35061774›Full record

ArticlePloS one2022

Levels and correlates of physical activity and capacity among HIV-infected compared to HIV-uninfected individuals.

Brenda Kitilya, George PrayGod, Robert Peck, John Changalucha, Kidola Jeremiah, Bazil Baltazar Kavishe, Henrik Friis, Suzanne Filteau, Daniel Faurholt-Jepsen, Rikke Krogh-Madsen and 2 more

Abstract read
In one paragraph

Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

  1. Article
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  10. Interventions for Type 2 Diabetes reduction among older people living with HIV in Harare.South African family practice : official journal of the South African Academy of Family Practice/Primary Care · 2024
    Review
  11. Article
  12. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Brenda KitilyaMwanza Research Centre, National Institute for Medical Research, Mwanza, Tanzania.ORCID 0000-0003-0734-5944
George PrayGodMwanza Research Centre, National Institute for Medical Research, Mwanza, Tanzania.
Robert PeckMwanza Research Centre, National Institute for Medical Research, Mwanza, Tanzania.
John ChangaluchaMwanza Research Centre, National Institute for Medical Research, Mwanza, Tanzania.
Kidola JeremiahMwanza Research Centre, National Institute for Medical Research, Mwanza, Tanzania.
Bazil Baltazar KavisheMwanza Research Centre, National Institute for Medical Research, Mwanza, Tanzania.ORCID 0000-0003-4839-4590
Henrik FriisDepartment of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark.
Suzanne FilteauDepartment of Population Health, London School of Hygiene and Tropical Medicine, London, United Kingdom.
Daniel Faurholt-JepsenDepartment of Infectious Diseases, Rigshospitalet, Copenhagen, Denmark.
Rikke Krogh-MadsenCentre for Physical Activity Research, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
Soren BrageMRC Epidemiology Unit, University of Cambridge, Cambridge, United Kingdom.ORCID 0000-0002-1265-7355
Mette F OlsenDepartment of Nutrition, Exercise and Sports, University of Copenhagen, Copenhagen, Denmark.ORCID 0000-0002-5742-6403

Funding

HIV, Sleep, Nocturnal Non-dipping, and Cardiovascular Disease: a Tanzanian CohortR01HL160332 · NHLBI · WEILL MEDICAL COLL OF CORNELL UNIV · PI PECK, ROBERT N · 2021 to 2025
$2.7M
Post-Doctoral Fellowship Training in HIV Clinical InvestigationD43TW011826 · FIC · WEILL MEDICAL COLL OF CORNELL UNIV · PI Daniel W Fitzgerald, Saidi Kapiga · 2021 to 2026
$1.9M
FIC NIH HHS D43 TW011826Medical Research Council MC_UU_00006/4Medical Research Council MC_UU_12015/3NHLBI NIH HHS R01 HL160332
6 · The paper itself

Abstract

introductionIn the HIV-infected individuals, physical activity improves physical strength, quality of life and reduces the risk of developing non-communicable diseases. In Sub-Saharan Africa, HIV-infected patients report being less active compared to HIV-uninfected individuals. We assessed the levels and correlates of objectively measured physical activity and capacity among HIV-infected antiretroviral therapy (ART)-naive individuals compared to HIV-uninfected individuals in Mwanza, Tanzania.

methodWe conducted a cross-sectional study among newly diagnosed HIV-infected ART-naive individuals and HIV-uninfected individuals frequency-matched for age and sex. Socio-demographic data, anthropometrics, CD4 counts, haemoglobin level, and C-reactive protein (CRP) were collected. Physical activity energy expenditure (PAEE) was assessed as measure of physical activity whereas sleeping heart rate (SHR) and grip strength were assessed as measures of physical capacity. Multivariable linear regression was used to assess the correlates associated with physical activity and capacity.

resultsA total of 272 HIV-infected and 119 HIV-uninfected individuals, mean age 39 years and 60% women participated in the study. Compared to HIV-uninfected individuals, HIV-infected had poorer physical activity and capacity: lower PAEE (-7.3 kj/kg/day, 95% CI: -11.2, -3.3), elevated SHR (7.7 beats/min, 95%CI: 10.1, 5.3) and reduced grip strength (-4.7 kg, 95%CI: -6.8, -2.8). In HIV-infected individuals, low body mass index, moderate-severe anaemia, low CD4 counts and high CRP were associated with lower physical activity and capacity. In HIV-uninfected individuals, abdominal obesity and moderate anaemia were associated with lower physical activity and capacity.

conclusionHIV-infected participants had lower levels of physical activity and capacity than HIV-uninfected participants. Correlates of physical activity and capacity differed by HIV status. Management of HIV and related conditions needs to be provided effectively in health care facilities. Interventions promoting physical activity in these populations will be of importance to improve their health and reduce the risk of non-communicable diseases.

Indexed as

AdultAfrica South of the SaharaAnthropometryAnti-Retroviral AgentsBody Mass IndexCD4 Lymphocyte CountCross-Sectional StudiesExerciseFemaleHIVHIV InfectionsHumansMaleMiddle AgedObesityQuality of LifeAnti-Retroviral Agents

Identifiers

PMID35061774
PMCPMC8782412

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.