ArticlePloS one2022
Antibody levels and protection after Hepatitis B vaccine in adult vaccinated healthcare workers in northern Uganda.
Article in PloS one, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- Occult hepatitis B virus infection among hepatitis B surface antigen negative vaccinated healthcare workers in East Gojjam zone hospitals.Scientific reports · 2026Article
- Anti-HBs persistence and anamnestic response among medical interns vaccinated in infancy.Scientific reports · 2025Article
- Impact ofVaccines · 2025Article
- Challenges to implementing mandatory hepatitis B vaccination: bridging immunization gaps among health workers in sub-Saharan Africa.Tropical medicine and health · 2025Article
- Hepatitis B vaccine coverage in health care students: a cross-sectional study in Vietnam.PloS one · 2025Article
- Hepatitis B Vaccine Nonresponse and Associated Risk Factors: Insights From a Cohort Study.Journal of tropical medicine · 2025Article
- Prevalence of hepatitis B surface antibody among previously vaccinated healthcare workers in Tashkent, Uzbekistan.Human vaccines & immunotherapeutics · 2024Article
- Article
- Immune response to GeneVac-BIJID regions · 2024Article
- Factors predicting the level of vaccine protection against hepatitis B virus infection among physicians and nurses in Šabac, Serbia.Arhiv za higijenu rada i toksikologiju · 2024Article
- Article
- Hepatitis B immunisation and immune status of nurses in a regional hospital in central South Africa.South African family practice : official journal of the South African Academy of Family Practice/Primary Care · 2024Article
- A review of health worker vaccination programs in low, middle and upper middle-income countries.Public health in practice (Oxford, England) · 2023Review
- Schistosoma mansoni infection alters the host pre-vaccination environment resulting in blunted Hepatitis B vaccination immune responses.PLoS neglected tropical diseases · 2023Article
- Distribution of Hepatitis B prevention services in Wakiso District, Central Uganda.PLOS global public health · 2023Article
- Assessment of hepatitis B vaccination status and hepatitis B surface antibody titres among health care workers in selected public health hospitals in Kenya.PLOS global public health · 2023Article
- Article
- Pre- and Post-Exposure Prophylaxis in Sexually Transmitted Diseases: An Uncharted Territory.Indian journal of dermatologyArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Hepatitis B vaccine has contributed to the reduction in hepatitis B virus infections and chronic disease globally. Screening to establish extent of vaccine induced immune response and provision of booster dose are limited in most low-and-middle income countries (LMICs). Our study investigated the extent of protective immune response and breakthrough hepatitis B virus infections among adult vaccinated healthcare workers in selected health facilities in northern Uganda. A cross-sectional study was conducted among 300 randomly selected adult hepatitis B vaccinated healthcare workers in Lira and Gulu regional referral hospitals in northern Uganda. Blood samples were collected and qualitative analysis of Hepatitis B surface antigen (HBsAg), Hepatitis B surface antigen antibody (HBsAb), Hepatitis B envelop antigen (HBeAg), Hepatitis B envelop antibody (HBeAb) and Hepatitis B core antibody (HBcAb) conducted using ELISA method. Quantitative assessment of anti-hepatitis B antibody (anti-HBs) levels was done using COBAS immunoassay analyzer. Multiple logistic regression was done to establish factors associated with protective anti-HBs levels (≥ 10mIU/mL) among adult vaccinate healthcare workers at 95% level of significance. A high proportion, 81.3% (244/300) of the study participants completed all three hepatitis B vaccine dose schedules. Two (0.7%, 2/300) of the study participants had active hepatitis B virus infection. Of the 300 study participants, 2.3% (7/300) had positive HBsAg; 88.7% (266/300) had detectable HBsAb; 2.3% (7/300) had positive HBeAg; 4% (12/300) had positive HBeAb and 17.7% (53/300) had positive HBcAb. Majority, 83% (249/300) had a protective hepatitis B antibody levels (≥10mIU/mL). Hepatitis B vaccine provides protective immunity against hepatitis B virus infection regardless of whether one gets a booster dose or not. Protective immune response persisted for over ten years following hepatitis B vaccination among the healthcare workers.
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