Evidence map›Paper›PMID 35061601›Full record

ArticlePhysics in medicine and biology2022

A dynamic blood flow model to compute absorbed dose to circulating blood and lymphocytes in liver external beam radiotherapy.

Shu Xing, Jungwook Shin, Jennifer Pursley, Camilo M Correa-Alfonso, Nicolas Depauw, Sean Domal, Julia Withrow, Wesley Bolch, Clemens Grassberger, Harald Paganetti

Abstract read
In one paragraph

Article in Physics in medicine and biology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Shu XingMassachusetts General Hospital, Harvard Medical School, Boston, MA, United States of America.ORCID 0000-0001-6728-5774
Jungwook ShinMassachusetts General Hospital, Harvard Medical School, Boston, MA, United States of America.
Jennifer PursleyMassachusetts General Hospital, Harvard Medical School, Boston, MA, United States of America.
Camilo M Correa-AlfonsoDepartment of Biomedical Engineering, University of Florida, Gainesville, FL, United States of America.ORCID 0000-0002-9756-6873
Nicolas DepauwMassachusetts General Hospital, Harvard Medical School, Boston, MA, United States of America.ORCID 0000-0002-0486-6149
Sean DomalDepartment of Biomedical Engineering, University of Florida, Gainesville, FL, United States of America.
Julia WithrowDepartment of Biomedical Engineering, University of Florida, Gainesville, FL, United States of America.
Wesley BolchDepartment of Biomedical Engineering, University of Florida, Gainesville, FL, United States of America.ORCID 0000-0002-7175-9968
Clemens GrassbergerMassachusetts General Hospital, Harvard Medical School, Boston, MA, United States of America.
Harald PaganettiMassachusetts General Hospital, Harvard Medical School, Boston, MA, United States of America.

Funding

Project 3: Enhanced Sensitivity of Tumors to Proton Beam Therapy: Mechanisms and Biomarkers.P01CA261669 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI HONG, THEODORE S · 2021 to 2025
$14.0M
Developing whole-body computational phantoms for blood dosimetry to model the impact of radiation on the immune systemR01CA248901 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI BOLCH, WESLEY E, PAGANETTI, HARALD · 2020 to 2024
$2.4M
A Computational Method to Calculate the Radiation Dose to CirculatingLymphocytesR21CA248118 · NCI · UNIVERSITY OF WASHINGTON · PI GRASSBERGER, CLEMENS · 2020 to 2020
$429k
Bio-Physical Modeling of Immuno-Radiotherapy Combinations based on Patient DataR21CA241918 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI GRASSBERGER, CLEMENS · 2019 to 2020
$399k
NCI NIH HHS P01 CA261669NCI NIH HHS R01 CA248901NCI NIH HHS R21 CA241918NCI NIH HHS R21 CA248118
6 · The paper itself

Abstract

We have developed a novel 4D dynamic liver blood flow model, capable of accurate dose estimation to circulating blood cells during liver-directed external beam radiotherapy, accounting for blood recirculation and radiation delivery time structure. Adult male and adult female liver computational phantoms with detailed vascular trees were developed to include the hepatic arterial, hepatic portal venous, and hepatic venous trees. A discrete time Markov Chain approach was applied to determine the spatiotemporal distribution of 10

Indexed as

ProtonsProton TherapyFemaleHumansLiverLymphocytesMaleMonte Carlo MethodRadiotherapy DosageRadiotherapy Planning, Computer-AssistedProtonsblood flow simulationcirculating lymphocytesliver radiation therapylymphopeniaproton therapy

Identifiers

PMID35061601
PMCPMC8985306

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.