ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2022
Hypoxemia increases blood-brain barrier permeability during extreme apnea in humans.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it, 31 citations in OpenAlex.
- GFAP and S100B: What You Always Wanted to Know and Never Dared to Ask.Frontiers in neurology · 2022Pooled it
- Acute hypoxia impairs posterior cerebral bioenergetics and memory in man.Experimental physiology · 2023Trial
- Artificial intelligence in contact sports research: Promise and peril for predicting and preventing brain injury.Experimental physiology · 2026Article
- Brain strain: Blood flow and metabolism in environmental extremes.Experimental physiology · 2026Review
- Hepcidin as an emerging predictor biomarker of leptomeningeal metastases in patients with metastatic breast cancer.BMC cancer · 2025Article
- Water and wisdom: Hydration as a defence against dementia.Experimental physiology · 2025Article
- Hypoxia in multiple sclerosis.Redox biology · 2025Review
- Physiological and molecular mechanisms of tolerance to hypoxia and oxygen deficiency resistance markers.Frontiers in molecular biosciences · 2025Review
- Impact of nasal high-flow humidified oxygen therapy on oxygenation index and respiratory function in patients with Stanford Type B aortic dissection and hypoxemia.American journal of translational research · 2025Article
- Trends in competitive freediving accidents.Diving and hyperbaric medicine · 2024Article
- Systemic determinants of brain health in ageing.Nature reviews. Neurology · 2024Review
- Review
- Blood-brain barrier disruption: a culprit of cognitive decline?Fluids and barriers of the CNS · 2024Review
- Lower systemic nitric oxide bioactivity, cerebral hypoperfusion and accelerated cognitive decline in formerly concussed retired rugby union players.Experimental physiology · 2023Article
- Oxidative Stress Response Kinetics after 60 Minutes at Different Levels (10% or 15%) of Normobaric Hypoxia Exposure.International journal of molecular sciences · 2023Article
- Compensatory mechanisms of reduced interhemispheric EEG connectivity during sleep in patients with apnea.Scientific reports · 2023Article
- Lifelong exposure to high-altitude hypoxia in humans is associated with improved redox homeostasis and structural-functional adaptations of the neurovascular unit.The Journal of physiology · 2023Article
- Multifunctional Polymeric Micelles for Cancer Therapy.Polymers · 2022Review
- Treatment of Neuronopathic Mucopolysaccharidoses with Blood-Brain Barrier-Crossing Enzymes: Clinical Application of Receptor-Mediated Transcytosis.Pharmaceutics · 2022Review
- Diagnostic biomarker kinetics: how brain-derived biomarkers distribute through the human body, and how this affects their diagnostic significance: the case of S100B.Fluids and barriers of the CNS · 2022Article
Corrections and comments
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Authors and funding
12 authors at 10 institutions in 6 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Voluntary asphyxia imposed by static apnea challenges blood-brain barrier (BBB) integrity in humans through transient extremes of hypertension, hypoxemia and hypercapnia. In the present study, ten ultra-elite breath-hold divers performed two maximal dry apneas preceded by normoxic normoventilation (NX: severe hypoxemia and hypercapnia) and hyperoxic hyperventilation (HX: absence of hypoxemia with exacerbating hypercapnia) with measurements obtained before and immediately after apnea. Transcerebral exchange of NVU proteins (ELISA, Single Molecule Array) were calculated as the product of global cerebral blood flow (gCBF, duplex ultrasound) and radial arterial to internal jugular venous concentration gradients. Apnea duration increased from 5 m 6 s in NX to 15 m 59 s in HX (
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Registered trials
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