ArticleScience advances2022
SF3B1 homeostasis is critical for survival and therapeutic response in T cell leukemia.
Registry-linked trialOpen access · goldAbstract read
In one paragraph
Article in Science advances, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07113132 (Role of SF3B1 Mutation in Assessment of Acute and Chronic Lymphatic Leukemia), which is not on this map. Cited by 25 papers.
0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
16.0field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Role of SF3B1 Mutation in Assessment of Acute and Chronic Lymphatic Leukemia
Who cites it
25 citing papers in PubMed, 58 citations in OpenAlex.
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- Casein kinase 2-mediated phosphorylation of the splicing factor SF3B3 plays a key role in esophageal squamous cell carcinoma progression.PLoS biology · 2026Article
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- HNRNPC and m6A RNA methylation control oncogenic transcription and metabolism in T-cell leukemia.Blood · 2025Article
- Revealing the role of U2AF1 in splicing regulation and chimeric RNA dynamics.Scientific reports · 2025Article
- Targeting PSMD14 combined with arachidonic acid induces synthetic lethality via FADS1 mScience advances · 2025Article
- Covalent targeting of splicing in T cells.Cell chemical biology · 2025Article
- Increased Prevalence of Germline Pathogenic CHEK2 Variants in Individuals With Pituitary Adenomas.The Journal of clinical endocrinology and metabolism · 2024Article
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- Targeting RBM39 through indisulam induced mis-splicing of mRNA to exert anti-cancer effects in T-cell acute lymphoblastic leukemia.Journal of experimental & clinical cancer research : CR · 2024Article
- The phosphatase inhibitor LB-100 creates neoantigens in colon cancer cells through perturbation of mRNA splicing.EMBO reports · 2024Article
- Approaches for Mapping and Analysis of R-loops.Current protocols · 2024Review
- The nuclear GYF protein CD2BP2/U5-52K is required for T cell homeostasis.Frontiers in immunology · 2024Article
- Variations of intronic branchpoint motif: identification and functional implications in splicing and disease.Communications biology · 2023Review
- Resistance mechanism to Notch inhibition and combination therapy in human T-cell acute lymphoblastic leukemia.Blood advances · 2023Article
- RNA helicase DHX15 exemplifies a unique dependency in acute leukemia.Haematologica · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
24 authors at 6 institutions in 2 countries.
Cuijuan HanDepartment of Biochemistry and Molecular Genetics, Northwestern University, Chicago, IL, USA.
Alireza Khodadadi-JamayranApplied Bioinformatics Laboratories, Office of Science and Research, New York University School of Medicine, New York, NY, USA.ORCID 0000-0003-2495-7504
Adam H LorchDepartment of Biochemistry and Molecular Genetics, Northwestern University, Chicago, IL, USA.
Qi JinDepartment of Biochemistry and Molecular Genetics, Northwestern University, Chicago, IL, USA.ORCID 0000-0002-4403-2560
Valentina SerafinDivision of Pediatric Hematology, Oncology and Stem Cell Transplant, Maternal and Child Health Department, Padua University, Padova, Italy.ORCID 0000-0001-6283-7728
Ping ZhuH3 Biomedicine Inc., Cambridge, MA, USA.
Yuliya PolitanskaDepartment of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID 0000-0002-6766-988X
Limin SunDepartment of Biochemistry and Molecular Genetics, Northwestern University, Chicago, IL, USA.
Blanca T Gutierrez-DiazDepartment of Biochemistry and Molecular Genetics, Northwestern University, Chicago, IL, USA.ORCID 0000-0001-7588-0274
Marina V PryzhkovaDepartment of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Hiam Abdala-ValenciaDepartment of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID 0000-0003-3384-5299
Elizabeth Thomas BartomDepartment of Biochemistry and Molecular Genetics, Northwestern University, Chicago, IL, USA.ORCID 0000-0002-5618-2582
Barbara BuldiniDivision of Pediatric Hematology, Oncology and Stem Cell Transplant, Maternal and Child Health Department, Padua University, Padova, Italy.
Giuseppe BassoDivision of Pediatric Hematology, Oncology and Stem Cell Transplant, Maternal and Child Health Department, Padua University, Padova, Italy.
Sadanandan E VeluDepartment of Chemistry, University of Alabama at Birmingham, Birmingham, AL, USA.ORCID 0000-0002-0342-2378
Kavitha SarmaGene Expression and Regulation Program, The Wistar Institute, Philadelphia, PA, USA.
Basil B MattamanaProteomics Center of Excellence, Northwestern University, Evanston, IL, USA.
Byoung-Kyu ChoProteomics Center of Excellence, Northwestern University, Evanston, IL, USA.ORCID 0000-0003-3370-6985
Rebecca C ObengDepartment of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL, USA.ORCID 0000-0001-8624-7108
Young Ah GooDepartment of Biochemistry and Molecular Genetics, Northwestern University, Chicago, IL, USA.
Philip W JordanDepartment of Biochemistry and Molecular Biology, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
Aristotelis TsirigosApplied Bioinformatics Laboratories, Office of Science and Research, New York University School of Medicine, New York, NY, USA.ORCID 0000-0002-7512-8477
Yalu ZhouDepartment of Biochemistry and Molecular Genetics, Northwestern University, Chicago, IL, USA.
Panagiotis NtziachristosDepartment of Biochemistry and Molecular Genetics, Northwestern University, Chicago, IL, USA.ORCID 0000-0001-6374-8954
Northwestern University · USUniversity of Padua · ITJohns Hopkins University · USOffice of Science · USThe Wistar Institute · USUniversity of Alabama at Birmingham · US
Funding
Tumor Environment and Metastasis (TEAM) Research ProgramP30CA060553 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LEONIDAS C. PLATANIAS · 1993 to 2026
$153.9MVaccine FacilityP30CA016087 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ANIRBAN MAITRA · 1985 to 2026
$83.1MTumor Microenvironment and MetastasisP30CA010815 · NCI · WISTAR INSTITUTE · PI Luis J Montaner · 1985 to 2026
$75.9MThe impact of changes in chromatin architecture on cancer phenotypes and tumor progressionP01CA229086 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Giorgio Inghirami · 2019 to 2026
$17.0MRegulation of microtubule organizing centers during mammalian gametogenesisR01GM117155 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI Philip W Jordan · 2016 to 2026
$4.3MTargeting Epigenetic Heterogeneity in Pediatric T cell leukemia: Epi-Clones as Drivers of ChemoresistanceR01CA252239 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI Aristotelis Tsirigos · 2021 to 2026
$3.7MEpigenetic regulation through the formation and resolution of R loopsDP2NS105576 · NINDS · WISTAR INSTITUTE · PI SARMA, KAVITHA · 2017 to 2017
$2.9MRemodeling of 3D chromatin in B cell acute leukemia and its impact on clinical outcomeR01CA260028 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI CARROLL, WILLIAM L., LIONNET, TIMOTHEE · 2021 to 2025
$2.2MBioinformatics Analysis of Next Generation Sequencing Data from Cancer CellsR50CA221848 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Elizabeth Thomas Bartom · 2017 to 2026
$1.8MExploring a new therapeutic approach through targeting epigenetic enzymes in ALLR00CA188293 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI NTZIACHRISTOS, PANAGIOTIS · 2015 to 2017
$747kTherapeutic targeting of demethylation-deubiquitination axis in acute leukemiaR01CA248770 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI NTZIACHRISTOS, PANAGIOTIS · 2020 to 2021
$726kNCI NIH HHS P01 CA229086NCI NIH HHS P30 CA010815NCI NIH HHS P30 CA016087NCI NIH HHS P30 CA060553NCI NIH HHS R00 CA188293NCI NIH HHS R01 CA248770NCI NIH HHS R01 CA252239NCI NIH HHS R50 CA221848NIGMS NIH HHS R01 GM117155NINDS NIH HHS DP2 NS105576
Abstract
The production of noncanonical mRNA transcripts is associated with cell transformation. Driven by our previous findings on the sensitivity of T cell acute lymphoblastic leukemia (T-ALL) cells to SF3B1 inhibitors, we identified that SF3B1 inhibition blocks T-ALL growth in vivo with no notable associated toxicity. We also revealed protein stabilization of the U2 complex component SF3B1 via deubiquitination. Our studies showed that SF3B1 inhibition perturbs exon skipping, leading to nonsense-mediated decay and diminished levels of DNA damage response-related transcripts, such as the serine/threonine kinase
Indexed as
Leukemia, T-CellPrecursor T-Cell Lymphoblastic Leukemia-LymphomaHomeostasisHumansMutationPhosphoproteinsRNA Splicing FactorsPhosphoproteinsRNA Splicing FactorsSF3B1 protein, human
Identifiers
What OpenQuestion holds
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LicenceCC BY
Read underepoch 390
Registered trials
NCT07113132ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.