Evidence map›Paper›PMID 35061215›Full record

ArticleClinical journal of gastroenterology2022

A rare case of pancreatic neuroendocrine neoplasm causing Cushing's syndrome.

Kazunori Nakaoka, Senju Hashimoto, Naoto Kawabe, Teiji Kuzuya, Seiji Yamada, Akira Sawaki, Kohei Funasaka, Mitsuo Nagasaka, Yoshihito Nakagawa, Ryoji Miyahara and 3 more

Abstract readCase Reports
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In one paragraph

Article in Clinical journal of gastroenterology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Kazunori NakaokaDepartment of Gastroenterology and Hepatology, Fujita Health University, 1-98 Dengakugakubo, Kutsukakecho, Toyoake, Aichi, 470-1192, Japan.
Senju HashimotoDepartment of Gastroenterology and Hepatology, Fujita Health University, 1-98 Dengakugakubo, Kutsukakecho, Toyoake, Aichi, 470-1192, Japan.
Naoto KawabeDepartment of Gastroenterology and Hepatology, Fujita Health University, 1-98 Dengakugakubo, Kutsukakecho, Toyoake, Aichi, 470-1192, Japan.
Teiji KuzuyaDepartment of Gastroenterology and Hepatology, Fujita Health University, 1-98 Dengakugakubo, Kutsukakecho, Toyoake, Aichi, 470-1192, Japan.
Seiji YamadaDepartment of Diagnostic Pathology, Fujita Health University, Toyoake, Aichi, Japan.
Akira SawakiDepartment of Gastroenterology and Hepatology, Fujita Health University, 1-98 Dengakugakubo, Kutsukakecho, Toyoake, Aichi, 470-1192, Japan.
Kohei FunasakaDepartment of Gastroenterology and Hepatology, Fujita Health University, 1-98 Dengakugakubo, Kutsukakecho, Toyoake, Aichi, 470-1192, Japan.
Mitsuo NagasakaDepartment of Gastroenterology and Hepatology, Fujita Health University, 1-98 Dengakugakubo, Kutsukakecho, Toyoake, Aichi, 470-1192, Japan.
Yoshihito NakagawaDepartment of Gastroenterology and Hepatology, Fujita Health University, 1-98 Dengakugakubo, Kutsukakecho, Toyoake, Aichi, 470-1192, Japan.
Ryoji MiyaharaDepartment of Gastroenterology and Hepatology, Fujita Health University, 1-98 Dengakugakubo, Kutsukakecho, Toyoake, Aichi, 470-1192, Japan.
Tomoyuki ShibataDepartment of Gastroenterology and Hepatology, Fujita Health University, 1-98 Dengakugakubo, Kutsukakecho, Toyoake, Aichi, 470-1192, Japan.
Tetsuya TsukamotoDepartment of Diagnostic Pathology, Fujita Health University, Toyoake, Aichi, Japan.
Yoshiki HirookaDepartment of Gastroenterology and Hepatology, Fujita Health University, 1-98 Dengakugakubo, Kutsukakecho, Toyoake, Aichi, 470-1192, Japan. yoshiki.hirooka@fujita-hu.ac.jp.ORCID http://orcid.org/0000-0001-9639-7425
Fujita Health University Hospital · JPFujita Health University · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pancreatic neuroendocrine neoplasms (PNENs) are relatively rare with a reported incidence of 1-2/100,000 and generally thought to originate from the precursor of the neuroendocrine cells including the islet and the pancreatic duct cells. About 65% of PNENs are non-functional. While insulinomas and gastrinomas are the most common functional PNENs, ACTH-producing PNENs are extremely rare. We herein present an extremely rare case of a patient with Cushing's syndrome caused by PNEN. A 46-year-old woman with edema in bilateral lower extremities and moon face was admitted with a suspicious pancreatic tumor. Enhanced computed tomography and endoscopic ultrasonography revealed a pancreatic tumor. The final diagnosis of ACTH-producing PNEN with Cushing's syndrome was based on clinical and biochemical test results and endocrinological studies. The symptoms associated Cushing's syndrome improved after pancreaticoduodenectomy for PNEN.

Indexed as

ACTH Syndrome, EctopicCushing SyndromeInsulinomaPancreatic NeoplasmsFemaleHumansMiddle AgedTomography, X-Ray ComputedCushing’s syndromeEctopic ACTH-producing tumorPancreatic neuroendocrine neoplasm

Identifiers

PMID35061215
OpenAlexW4206362722

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.