Evidence map›Paper›PMID 35061138›Full record

ReviewCurrent psychiatry reports2022

Gastrointestinal Interoception in Eating Disorders: Charting a New Path.

Sahib S Khalsa, Laura A Berner, Lisa M Anderson

Open access · hybridAbstract readReview
In one paragraph

Review in Current psychiatry reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed, 1 pooled it
15.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 1 synthesis or guideline pooled it, 86 citations in OpenAlex.

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  16. Altered Gastrointestinal Interoception in Anorexia Nervosa Predicts Relapse.medRxiv : the preprint server for health sciences · 2025
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 3 institutions in 1 country.

Sahib S KhalsaLaureate Institute for Brain Research, 6655 South Yale Ave, Tulsa, OK, 74136, USA. skhalsa@laureateinstitute.org.
Laura A BernerDepartment of Psychiatry, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Lisa M AndersonDepartment of Psychiatry and Behavioral Sciences, University of Minnesota Medical School, Minneapolis, MN, USA.
Icahn School of Medicine at Mount Sinai · USLaureate Institute for Brain Research · USUniversity of Minnesota Medical Center · US

Funding

A neurocomputational assay of gastrointestinal interoception in anorexia nervosaR01MH127225 · NIMH · LAUREATE INSTITUTE FOR BRAIN RESEARCH · PI KHALSA, SAHIB S., PAULUS, MARTIN P. · 2021 to 2025
$3.2M
Neural Basis of Meal Related Interoceptive Dysfunction in Anorexia NervosaK23MH112949 · NIMH · LAUREATE INSTITUTE FOR BRAIN RESEARCH · PI KHALSA, SAHIB · 2017 to 2021
$994k
The Influences of Eating and Fasting on Inhibitory Control in Bulimia Nervosa: A Computational Neuroimaging StudyK23MH118418 · NIMH · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI BERNER, LAURA A. · 2019 to 2023
$963k
Neural Bases of Disgust Conditioning in Anorexia NervosaK23MH123910 · NIMH · UNIVERSITY OF MINNESOTA · PI ANDERSON, LISA M · 2020 to 2024
$821k
NIMH NIH HHS K23 MH112949NIMH NIH HHS K23 MH118418NIMH NIH HHS K23 MH123910NIMH NIH HHS R01 MH127225
6 · The paper itself

Abstract

purpose of reviewAbnormal interoception has been consistently observed across eating disorders despite limited inclusion in diagnostic conceptualization. Using the alimentary tract as well as recent developments in interoceptive neuroscience and predictive processing as a guide, the current review summarizes evidence of gastrointestinal interoceptive dysfunction in eating disorders. RECENT

findingsEating is a complex process that begins well before and ends well after food consumption. Abnormal prediction and prediction-error signals may occur at any stage, resulting in aberrant gastrointestinal interoception and dysregulated gut sensations in eating disorders. Several interoceptive technologies have recently become available that can be paired with computational modeling and clinical interventions to yield new insights into eating disorder pathophysiology. Illuminating the neurobiology of gastrointestinal interoception in eating disorders requires a new generation of studies combining experimental probes of gut physiology with computational modeling. The application of such techniques within clinical trials frameworks may yield new tools and treatments with transdiagnostic relevance.

Indexed as

Anorexia NervosaBulimia NervosaFeeding and Eating DisordersInteroceptionHumansNeurobiologyAnorexia nervosaAvoidant/restrictive food intake disorderBinge-eating disorderBulimia nervosaDigestionInteroceptive awareness

Identifiers

PMID35061138
PMCPMC8898253
OpenAlexW4205091867

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.