Evidence map›Paper›PMID 35061099›Full record

SynthesisSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2022

Sexual problems in patients with hematological diseases: a systematic literature review.

Corien Eeltink, Alaa Embaby, Luca Incrocci, Johannes C F Ket, Sarah J Liptrott, Irma Verdonck-de Leeuw, Sonja Zweegman

Open access · greenAbstract readSystematic Review
PubMed Publisher
In one paragraph

Synthesis in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
2.8field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Sexual Dysfunction in Patients with Chronic Non-Genital Physical Disease: An Umbrella Review.International journal of environmental research and public health · 2025
    Pooled it
  2. Article
  3. Nurses' attitudes toward addressing sexual health in their professional practice within cancer care: a Danish cross-sectional study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
  4. Sexual health in older adults with hematologic malignancies - a sub-analysis of a Danish cross-sectional study.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
  5. Review
  6. Sexual dysfunction and its impact on quality of life among female haematological cancer patients: a cross-sectional study in Malaysia.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2025
    Article
  7. Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 6 institutions in 3 countries.

Corien EeltinkCancer Center Amsterdam (CCA), Amsterdam UMC, VU University Medical Center, Amsterdam, The Netherlands. C.Eeltink@amsterdamumc.nl.
Alaa EmbabyDepartment of Clinical Pharmacology, Netherlands Cancer Institute, Antoni van Leeuwenhoekziekenhuis, Amsterdam, The Netherlands.
Luca IncrocciDepartment of Radiotherapy-Oncology/Sexology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands.
Johannes C F KetMedical Library, Vrije Universiteit, Amsterdam, The Netherlands.
Sarah J LiptrottIEO, European Institute of Oncology IRCCS, Milan, Italy.
Irma Verdonck-de LeeuwDepartment of Otolaryngology-Head and Neck Surgery, Amsterdam Public Health Research Institute, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
Sonja ZweegmanCancer Center Amsterdam (CCA), Amsterdam UMC, VU University Medical Center, Amsterdam, The Netherlands.
Amsterdam UMC Location VUmc · NLAmsterdam University Medical Centers · NLEnte Ospedaliero Cantonale · CHErasmus MC Cancer Institute · NLThe Netherlands Cancer Institute · NLVrije Universiteit Amsterdam · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeSexual problems are frequently reported by recipients of hematopoietic stem cell transplantation (HCT). However, little is known about the impact of hematological malignancies and their treatments, without HCT being a part of the treatment regimen. The goal of this systematic review was to examine the prevalence of various sexual problems among patients treated for hematological malignancies without HCT.

methodsThe work focused on online databases available from their inception until 11 November 2020. The data related to sexuality in adult patients diagnosed with hematological malignancies. Selected studies were appraised for methodological quality.

resultsTwenty-four studies were included. Twenty-two studies were observational cross-sectional cohort studies, and two studies had a prospective longitudinal design; fourteen studies used non-validated instruments; only two studies used the multidimensional concept of sexuality; six studies compared sexual problems in the target population with reference data. Based on the few high-quality studies, sexual problems occurred in 18-50% of acute leukemia, Hodgkin lymphoma, and non-Hodgkin lymphoma patients.

conclusionUnderstanding sexual problems in patients treated for hematological malignancies without HCT is not only hampered by the variability in methodology, but also by the lack of research on patients using novel therapies. The exact impact of the diagnosis and treatment of a hematological malignancy on sexual function remains to be answered. Longitudinal studies focusing on the effects of the diagnosis and treatment of hematological malignancies on sexuality using validated questionnaires and comparison with normative data are hugely needed.

Indexed as

Hematologic NeoplasmsHematopoietic Stem Cell TransplantationAdultCross-Sectional StudiesHumansProspective StudiesSexualityHematological malignancySexual dissatisfactionSexual functionSexualitySexual problemSystematic review

Identifiers

PMID35061099
OpenAlexW4206489870

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.