Evidence map›Paper›PMID 35061010›Full record

ArticleTranslational vision science & technology2022

Potential-Driven Electrochemical Clearing of Ex Vivo Alkaline Corneal Injuries.

Katelyn K Dilley, Pamela A Borden, Yueqiao Qu, Andrew E Heidari, Karthik R Prasad, Yan Li, Chung Ho Sun, Zhongping Chen, Sehwan Kim, Michael G Hill and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational vision science & technology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Katelyn K DilleyBeckman Laser Institute & Medical Clinic, University of California-Irvine, Irvine, CA, USA.
Pamela A BordenBeckman Laser Institute & Medical Clinic, University of California-Irvine, Irvine, CA, USA.
Yueqiao QuBeckman Laser Institute & Medical Clinic, University of California-Irvine, Irvine, CA, USA.
Andrew E HeidariBeckman Laser Institute & Medical Clinic, University of California-Irvine, Irvine, CA, USA.
Karthik R PrasadBeckman Laser Institute & Medical Clinic, University of California-Irvine, Irvine, CA, USA.
Yan LiBeckman Laser Institute & Medical Clinic, University of California-Irvine, Irvine, CA, USA.
Chung Ho SunBeckman Laser Institute & Medical Clinic, University of California-Irvine, Irvine, CA, USA.
Zhongping ChenBeckman Laser Institute & Medical Clinic, University of California-Irvine, Irvine, CA, USA.
Sehwan KimBeckman Laser Institute-Korea, Department of Biomedical Engineering, Dankook University, Cheonan-si, Chungnam, Republic of Korea.
Michael G HillDepartment of Chemistry, Occidental College, Los Angeles, CA, USA.
Brian J F WongBeckman Laser Institute & Medical Clinic, University of California-Irvine, Irvine, CA, USA.

Funding

University of California Health Participation in the National COVID Cohort Collaborative (N3C)UL1TR001414 · NCATS · UNIVERSITY OF CALIFORNIA-IRVINE · PI COOPER, DAN M, VILAIN, ERIC J. · 2015 to 2023
$35.1M
Virtual Photonocs TechnologiesP41EB015890 · NIBIB · UNIVERSITY OF CALIFORNIA-IRVINE · PI BOTVINICK, ELLIOT LAWRENCE · 2012 to 2017
$7.0M
Phase resolved ARF optical coherence elastography for intravascular imagingR01HL125084 · NHLBI · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHEN, ZHONGPING, ZHOU, QIFA · 2014 to 2023
$5.6M
In vivo Imaging and Quantification of Cilia Beating Dynamics Using Phase-Resolved Optical Imaging TechnologyR01EB030024 · NIBIB · UNIVERSITY OF CALIFORNIA-IRVINE · PI CHEN, ZHONGPING, WONG, BRIAN · 2020 to 2024
$2.3M
The Electromechanical Reshaping of CorneaR15EY032273 · NEI · OCCIDENTAL COLLEGE · PI MICHAEL G HILL · 2021 to 2026
$679k
NCATS NIH HHS UL1 TR001414NEI NIH HHS R15 EY032273NHLBI NIH HHS R01 HL125084NIBIB NIH HHS P41 EB015890NIBIB NIH HHS R01 EB030024
6 · The paper itself

Abstract

Purpose: Corneal chemical injuries (CCI) obscure vision by opacifying the cornea; however, current treatments may not fully restore clarity. Here, we investigated potential-driven electrochemical treatment (P-ECT) to restore clarity after alkaline-based CCI in ex vivo rabbit corneas and examined collagen fiber orientation changes using second harmonic generation (SHG). Methods: NaOH was applied to the corneas of intact New Zealand white rabbit globes. P-ECT was performed on the opacified cornea while optical coherence tomography (OCT) imaging (∼35 frames per second) was simultaneously performed. SHG imaging evaluated collagen fiber structure before NaOH application and after P-ECT. Irrigation with water served as a control. Results: P-ECT restored local optical clarity after NaOH exposure. OCT imaging shows both progression of NaOH injury and the restoration of clarity in real time. Analysis of SHG z-stack images show that collagen fibril orientation is similar between control, NaOH-damaged, and post-P-ECT corneas. NaOH-injured corneas flushed with water (15 minutes) show no restoration of clarity. Conclusions: P-ECT may be a means to correct alkaline CCI. Collagen fibril orientation does not change after NaOH exposure or P-ECT, suggesting that no irreversible matrix level fiber changes occur. Further studies are required to determine the mechanism for corneal clearing and to ascertain the optimal electrical dosimetry parameters and electrode designs. Translational Relevance: Our findings suggest that P-ECT is a potentially effective, low-cost treatment for alkaline CCI.

Indexed as

Corneal InjuriesAnimalsCorneaRabbitsSkin

Identifiers

PMID35061010
PMCPMC8787648

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.