Evidence map›Paper›PMID 35060905›Full record

ArticleeLife2022

RNA binding to human METTL3-METTL14 restricts

Shan Qi, Javier Mota, Siu-Hong Chan, Johanna Villarreal, Nan Dai, Shailee Arya, Robert A Hromas, Manjeet K Rao, Ivan R Corrêa, Yogesh K Gupta

Open access · goldAbstract read
In one paragraph

Article in eLife, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 26 citations in OpenAlex.

  1. Article
  2. Targeting intracellular mRNA mJournal of advanced research · 2026
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  10. Interconnections between mLife science alliance · 2024
    Review
  11. Review
  12. Ghost authors revealed: The structure and function of human NWiley interdisciplinary reviews. RNA · 2023
    Review
  13. Article
  14. mActa biochimica et biophysica Sinica · 2023
    Review
  15. Review
  16. Article
  17. Article
  18. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

Shan Qi *Greehey Children's Cancer Research Institute, University of Texas Health at San Antonio, San Antonio, United States.ORCID https://orcid.org/0000-0003-0175-6267
Javier Mota *Greehey Children's Cancer Research Institute, University of Texas Health at San Antonio, San Antonio, United States.
Siu-Hong ChanNew England Biolabs, Ipswich, United States.
Johanna VillarrealGreehey Children's Cancer Research Institute, University of Texas Health at San Antonio, San Antonio, United States.
Nan DaiNew England Biolabs, Ipswich, United States.
Shailee AryaGreehey Children's Cancer Research Institute, University of Texas Health at San Antonio, San Antonio, United States.
Robert A HromasDivision of Hematology and Medical Oncology, Department of Medicine, University of Texas Health at San Antonio, San Antonio, United States.
Manjeet K RaoGreehey Children's Cancer Research Institute, University of Texas Health at San Antonio, San Antonio, United States.
Ivan R CorrêaNew England Biolabs, Ipswich, United States.ORCID https://orcid.org/0000-0002-3169-6878
Yogesh K GuptaGreehey Children's Cancer Research Institute, University of Texas Health at San Antonio, San Antonio, United States.ORCID https://orcid.org/0000-0001-6372-5007
The University of Texas Health Science Center at San Antonio · USNew England Biolabs (China) · CN

Funding

Institute for Integration of Medicine & Science: A Partnership to Improve HealthUL1TR002645 · NCATS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI CLARK, ROBERT A, HARGREAVES, KENNETH M · 2018 to 2022
$20.4M
EEPD1 Repair of Stressed Replication ForksR01CA205224 · NCI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Robert A Hromas · 2016 to 2026
$3.3M
Mechanism-based Targeting of the RNA Processing Machinery of SARS-CoV-2R01AI161363 · NIAID · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI GUPTA, YOGESH K · 2021 to 2025
$3.2M
NCATS NIH HHS UL1 TR002645NCI NIH HHS R01 CA205224NIAID NIH HHS R01 AI161363
6 · The paper itself

Abstract

Methyltransferase like-3 (METTL3) and METTL14 complex transfers a methyl group from

Indexed as

DeoxyadenosinesDNA MethylationDNA, Single-StrandedHumansMethyltransferasesRNADeoxyadenosinesDNA, Single-StrandedMethyltransferasesMETTL14 protein, humanMETTL3 protein, humanRNAbiochemistrychemical biologychemical modificationDNA methylationhumanmedicineRNA/DNA bindingRNA/DNA modificationsRNA methylationsam-dependent methyltransferase

Identifiers

PMID35060905
PMCPMC8828048
OpenAlexW4205904117

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.