ArticleAmerican journal of physiology. Heart and circulatory physiology2022
Acute heat exposure improves microvascular function in skeletal muscle of aged adults.
Article in American journal of physiology. Heart and circulatory physiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 21 citations in OpenAlex.
- Feasibility of unsupervised, home-based leg heat therapy in older adults: a pilot, sham-controlled trial.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Trial
- Short-term endurance training in the cold with layered clothing mitigates perceptual strain during exercise in the heat.European journal of applied physiology · 2026Article
- Plantar Foot Microvascular Reactivity and Oxygenation in Type 2 Diabetes and Peripheral Artery Disease: An Exploratory Study.Microcirculation (New York, N.Y. : 1994) · 2026Article
- Heat Therapy: Targeting Health, Disease, and Disability.Comprehensive Physiology · 2026Review
- Passive thigh heating improves peak force production in younger adults and early isokinetic force production in younger and older adults.Experimental physiology · 2025Article
- Systemic cardiovascular and carotid baroreflex support of arterial pressure during recovery from passive heat stress in young and older adults.Physiological reports · 2025Article
- Improving glycemic control via heat therapy in older adults at risk for Alzheimer's disease (FIGHT-AD): a pilot study.Journal of applied physiology (Bethesda, Md. : 1985) · 2025Article
- Hot Water Immersion as a Means to Prevent Cardiovascular Disease and Associated Mortality.Current cardiology reviews · 2025Review
- The Effects of Combined Contrast Heat Cold Pressure Therapy on Post-Exercise Muscle Recovery in MMA Fighters: A Randomized Controlled Trial.Journal of human kinetics · 2024Article
- Cyclooxygenase inhibition does not blunt thermal hyperemia in skeletal muscle of humans.Journal of applied physiology (Bethesda, Md. : 1985) · 2024Article
- The acute effect of whole-body heat therapy on peripheral and cerebral vascular reactivity in Black and White females.Microvascular research · 2023Article
- Control of blood pressure in the cold: differentiation of skin and skeletal muscle vascular resistance.Experimental physiology · 2023Article
- New developments in translational microcirculatory research.American journal of physiology. Heart and circulatory physiology · 2022Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Acute heat exposure improves microvascular function in aged adults as assessed using reactive hyperemia. The cutaneous and skeletal muscle microcirculations are thought to contribute to this response, but this has never been confirmed due to the methodological challenges associated with differentiating blood flow between these vascular beds. We hypothesized that acute hot water immersion would improve endothelial-dependent, but not endothelial-independent vasodilation in the microcirculation of the vastus lateralis muscle in healthy aged adults. Participants (70 ± 5 yr) were immersed for 60 min in thermoneutral (36°C) or hot (40°C) water. Ninety minutes following immersion, skeletal muscle microdialysis was used to bypass the cutaneous circulation and directly assess endothelial-dependent and endothelial-independent vasodilation by measuring the local hyperemic response to graded infusions of acetylcholine (ACh, 27.5 and 55.0 mM) and sodium nitroprusside (SNP, 21 and 42 mM), respectively. The hyperemic response to 27.5 mM ACh did not differ between thermal conditions (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.