Evidence map›Paper›PMID 35060656›Full record

ArticleJournal of mass spectrometry : JMS2022

Deuterium-depleted water: A new tracer to label pulmonary surfactant lipids in adult rabbits.

Manuela Simonato, Francesca Ricci, Chiara Catozzi, Matteo Storti, Sonia Giambelluca, Alessio Correani, Fabrizio Salomone, Paola Cogo, Virgilio Carnielli

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of mass spectrometry : JMS, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.5field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 2 countries.

Manuela SimonatoPCare Laboratory, Fondazione Istituto di Ricerca Pediatrica, 'Città della Speranza', Padua, Italy.ORCID https://orcid.org/0000-0002-2745-7305
Francesca RicciNeonatology and Pulmonary Rare Disease Unit, Pharmacology & Toxicology Department Corporate Preclinical R&D, Chiesi, Parma, Italy.
Chiara CatozziNeonatology and Pulmonary Rare Disease Unit, Pharmacology & Toxicology Department Corporate Preclinical R&D, Chiesi, Parma, Italy.
Matteo StortiDepartment of Chemical & Life Sciences and Environmental Sustainability, University of Parma, Parma, Italy.
Sonia GiambellucaPCare Laboratory, Fondazione Istituto di Ricerca Pediatrica, 'Città della Speranza', Padua, Italy.
Alessio CorreaniDivision of Neonatology, Polytechnic University of Marche and 'G. Salesi' Children's Hospital, Ancona, Italy.
Fabrizio SalomoneNeonatology and Pulmonary Rare Disease Unit, Pharmacology & Toxicology Department Corporate Preclinical R&D, Chiesi, Parma, Italy.
Paola CogoDepartment of Medicine, University Hospital Santa Maria della Misericordia, University of Udine, Udine, Italy.
Virgilio CarnielliDivision of Neonatology, Polytechnic University of Marche and 'G. Salesi' Children's Hospital, Ancona, Italy.
BioClinica (United States) · USMarche Polytechnic University · ITUniversity of Padua · ITUniversity of Parma · ITUniversity of Udine · IT

Funding

Chiesi Farmaceutici
6 · The paper itself

Abstract

Stable isotope tracing can be safely used for metabolic studies in animals and humans. The endogenous biosynthesis of lipids (lipogenesis) is a key process throughout the entire life but especially during brain and lung growth. Adequate synthesis of pulmonary surfactant lipids is indispensable for life. With this study, we report the use of deuterium-depleted water (DDW), suitable for human consumption, as metabolic precursor for lipogenesis. We studied 13 adult rabbits for 5 days. Four rabbits drank tap water (TW) and served as controls; in four animals, DDW was substituted to drinking water, whereas five drank deuterium-enriched water (DEW). After 5 days, a blood sample and a bronchoalveolar lavage (BAL) sample were collected. The

Indexed as

Drinking WaterPulmonary SurfactantsAnimalsDeuteriumPhosphatidylcholinesPhospholipidsRabbitsDeuteriumDrinking WaterPhosphatidylcholinesPhospholipidsPulmonary Surfactantsdeuterium-depleted waterdeuterium-enriched waterisotope ratio mass spectrometrylipogenesispulmonary surfactanttracer

Identifiers

PMID35060656
PMCPMC9285457
OpenAlexW4206780489

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.