Evidence map›Paper›PMID 35060361›Full record

ArticleAnnals of clinical and translational neurology2022

Long COVID-19: Objectifying most self-reported neurological symptoms.

Julia Bungenberg, Karen Humkamp, Christian Hohenfeld, Marcus Immanuel Rust, Ummehan Ermis, Michael Dreher, Niels-Ulrik Korbinian Hartmann, Gernot Marx, Ferdinand Binkofski, Carsten Finke and 3 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Annals of clinical and translational neurology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 86 papers, 11 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
86citing papers in PubMed, 11 pooled it
15.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

86 citing papers in PubMed, 11 syntheses or guidelines pooled it, 131 citations in OpenAlex.

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26 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Julia BungenbergDepartment of Neurology, RWTH Aachen University, Aachen, Germany.
Karen HumkampDepartment of Neurology, RWTH Aachen University, Aachen, Germany.
Christian HohenfeldDepartment of Neurology, RWTH Aachen University, Aachen, Germany.
Marcus Immanuel RustDepartment of Neurology, RWTH Aachen University, Aachen, Germany.
Ummehan ErmisDepartment of Neurology, RWTH Aachen University, Aachen, Germany.
Michael DreherDepartment of Pneumonology and Internal Intensive Care Medicine, RWTH University Hospital, Aachen, Germany.
Niels-Ulrik Korbinian HartmannDepartment of Cardiology, Angiology and Internal Intensive Care Medicine, RWTH University Hospital, Aachen, Germany.
Gernot MarxDepartment of Operative Intensive und Intermediate Care Medicine, RWTH University Hospital, Aachen, Germany.
Ferdinand BinkofskiDivision of Clinical Cognitive Sciences, Department of Neurology, RWTH Aachen University, Aachen, Germany.
Carsten FinkeDepartment of Neurology, Charité - Universitätsmedizin Berlin, Berlin, Germany.ORCID 0000-0002-7665-1171
Jörg B SchulzDepartment of Neurology, RWTH Aachen University, Aachen, Germany.ORCID 0000-0002-8903-0593
Ana Sofia CostaDepartment of Neurology, RWTH Aachen University, Aachen, Germany.ORCID 0000-0002-1999-6616
Kathrin ReetzDepartment of Neurology, RWTH Aachen University, Aachen, Germany.ORCID 0000-0002-9730-9228
Forschungszentrum Jülich · DERWTH Aachen University · DEUniversitätsklinikum Aachen · DECharité - Universitätsmedizin Berlin · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesWe aimed to objectify and compare persisting self-reported symptoms in initially hospitalized and non-hospitalized patients after infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) by applying clinical standardized measures.

methodsWe conducted a cross-sectional study of adult patients with confirmed SARS-CoV-2 infection including medical history, neurological examination, blood markers, neuropsychological testing, patient-reported outcome measures (PROMs), and brain magnetic resonance imaging (MRI).

resultsFifty patients with persisting symptoms for at least 4 weeks were included and classified by initial hospitalization status. Median time from SARS-CoV-2 detection to investigation was 29.3 weeks (range 3.3-57.9). Although individual cognitive performance was generally within the normative range in both groups, mostly mild deficits were found in attention, executive functions, and memory. Hospitalized patients performed worse in global cognition, logical reasoning, and processes of verbal memory. In both groups, fatigue severity was associated with reduced performance in attention and psychomotor speed tasks (r

interpretationRegardless of initial COVID-19 severity, an individuals' mental and physical health can be severely impaired in the long-term limitedly objectified by clinical standard diagnostic with abnormalities primarily found in hospitalized patients. This needs to be considered when planning rehabilitation therapies and should give rise to new biomarker research.

Indexed as

Quality of LifeSelf ReportAdultCOVID-19Cross-Sectional StudiesFemaleHospitalizationHumansMaleMiddle AgedNervous System DiseasesPost-Acute COVID-19 SyndromeSARS-CoV-2

Identifiers

PMID35060361
PMCPMC8862437
OpenAlexW4206412349

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.