Evidence map›Paper›PMID 35060260›Full record

ArticleHealth expectations : an international journal of public participation in health care and health policy2022

'We have goals but [it is difficult]'. Barriers to antiretroviral therapy adherence among women using alcohol and other drugs living with HIV in South Africa.

Jacqueline W Ndirangu, Margaret W Gichane, Felicia A Browne, Courtney P Bonner, William A Zule, Erin N Cox, Kevin M Smith, Tara Carney, Wendee M Wechsberg

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Health expectations : an international journal of public participation in health care and health policy, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02733003 (Implementation Research for Vulnerable Women in South Africa), which is not on this map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02733003 nacompletednot on this map

Implementation Research for Vulnerable Women in South Africa

TypeinterventionalSponsorRTI InternationalRan2015 to 2018Enrolled564ConditionsHIV, Substance AbuseArmsWomen's Health CoOp (WHC)
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it, 10 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Primary health care providers' views on managing substance use among people living with HIV.African journal of primary health care & family medicine · 2023
    Article
  7. Article
  8. 'We have goals but [it is difficult]'. Barriers to antiretroviral therapy adherence among women using alcohol and other drugs living with HIV in South Africa.Health expectations : an international journal of public participation in health care and health policy · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Jacqueline W NdiranguSubstance Use, Gender, and Applied Research Program, RTI International, Research Triangle Park, North Carolina, USA.ORCID 0000-0001-8346-7359
Margaret W GichaneSubstance Use, Gender, and Applied Research Program, RTI International, Research Triangle Park, North Carolina, USA.
Felicia A BrowneSubstance Use, Gender, and Applied Research Program, RTI International, Research Triangle Park, North Carolina, USA.
Courtney P BonnerSubstance Use, Gender, and Applied Research Program, RTI International, Research Triangle Park, North Carolina, USA.
William A ZuleSubstance Use, Gender, and Applied Research Program, RTI International, Research Triangle Park, North Carolina, USA.
Erin N CoxSubstance Use, Gender, and Applied Research Program, RTI International, Research Triangle Park, North Carolina, USA.
Kevin M SmithGillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA.
Tara CarneyAlcohol, Tobacco and Other Drug Research Unit, South African Medical Research Council, Tygerberg, South Africa.
Wendee M WechsbergSubstance Use, Gender, and Applied Research Program, RTI International, Research Triangle Park, North Carolina, USA.ORCID 0000-0002-5146-6463
RTI International · USUniversity of North Carolina at Chapel Hill · USSouth African Medical Research Council · ZA

Funding

Implementation Research for Vulnerable Women in South AfricaR01AA022882 · NIAAA · RESEARCH TRIANGLE INSTITUTE · PI WECHSBERG, WENDEE M · 2014 to 2018
$3.2M
NIAAA NIH HHS R01 AA022882
6 · The paper itself

Abstract

backgroundWomen living with HIV who misuse alcohol and live in economically disadvantaged settings in South Africa experience a multitude of contextual barriers as they navigate the HIV care continuum. The Women's Health CoOp (WHC), a brief, woman-focused, behavioural, evidence-based intervention, has been shown to be effective in reducing heavy drinking and improving HIV-related outcomes among this key population. However, these women face other broader socioecological barriers to antiretroviral therapy (ART) adherence.

methodsThe WHC was implemented in a modified, stepped-wedge implementation science trial in public health clinics and substance use treatment programmes in Cape Town, South Africa. A qualitative substudy was conducted to explore barriers to HIV treatment adherence among women enrolled in this trial. Eight focus group discussions were conducted with 69 participants 6 months after completion of the WHC workshops. Focus groups were audio-recorded (with consent), transcribed verbatim and analysed using a thematic approach.

resultsThe mean age of the participants was 33 years and the mean self-reported number of drinks per day was 13. The main contextual factors influencing participants' ART adherence were intrapersonal-level factors (substance use, financial constraints, food insecurity; community-level factors (anticipated and enacted stigma, community violence) and institutional-level factors (patient-provider relationships, health facility barriers, environmental stigma).

conclusionComprehensive interventions addressing the contextual barriers and unique challenges faced by women who misuse alcohol in low-resource settings that intersect with HIV treatment nonadherence should be implemented in tandem with successful biobehavioural HIV interventions for long-term effectiveness and sustainability. PATIENT OR PUBLIC CONTRIBUTION: Our South African community collaborative board has been involved throughout this study; participants and clinic staff voices have been essential in our interpretation of these findings.

Indexed as

GoalsHIV InfectionsAdultAnti-Retroviral AgentsFemaleHumansPatient ComplianceSouth AfricaAnti-Retroviral Agentsalcohol and other drugs (AOD)antiretroviral therapy (ART)gender-focusedHIV care continuumimplementation sciencesocioecological barriers

Identifiers

PMID35060260
PMCPMC8957738
OpenAlexW4206735946

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.