Evidence map›Paper›PMID 35060222›Full record

Trial reportPsycho-oncology2022

How does the Untire app alleviate cancer-related fatigue? A longitudinal mediation analysis.

Simon S Spahrkäs, Anne Looijmans, Robbert Sanderman, Mariët Hagedoorn

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Psycho-oncology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05891431 (Acceptability and Preliminary Effectiveness of a Mobile Health Intervention), which is not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05891431 naactive not recruitingnot on this mapstarted 2023, after this paper: background citation

Acceptability and Preliminary Effectiveness of a Mobile Health Intervention (Untire App) for Adult Cancer Patients and Survivors With Cancer Related Fatigue: A Pilot Clinical Study

TypeinterventionalSponsorUniversity of BathRan2023 to 2025Enrolled34ConditionsCancer-related Problem/Condition, Cancer-related FatigueArmsUntire mobile app
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 12 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Current non-pharmacological practices for cancer-related fatigue in oncology rehabilitation: results of a national provider survey.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026
    Article
  4. Article
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Simon S SpahrkäsDepartment of Health Psychology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.ORCID 0000-0003-1039-8887
Anne LooijmansDepartment of Health Psychology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.ORCID 0000-0002-3333-562X
Robbert SandermanDepartment of Health Psychology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.ORCID 0000-0002-0823-1159
Mariët HagedoornDepartment of Health Psychology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.ORCID 0000-0003-3444-3662
University Medical Center Groningen · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveA waiting-list randomized controlled trial supported the effectiveness of the multimodal Untire app in reducing cancer-related fatigue (CRF) in cancer patients and survivors. However, little is known about the causal mechanisms of different app components through which the intervention effect was achieved. We aim to examine whether specifically targeted factors (i.e., fatigue catastrophizing, depression, mindfulness, sleep, and physical activity) mediated the intervention effects of the Untire app on fatigue outcomes.

methodsSeven hundred ninety-nine persons with CRF were randomized (2:1) into intervention (n = 519) and waiting-list control (n = 280) groups. Self-report data on the primary outcome fatigue severity and interference and the abovementioned potential mediators were collected at baseline and 12 weeks. Participants who completed the 12-week assessment were included in the analyses (intervention = 159; control = 176). We performed longitudinal multi-categorical multiple mediation analysis using PROCESS macro to examine whether the potential mediators explained the overall intervention effects.

resultsImprovements in fatigue catastrophizing (bootstrap 95% CI (-0.110; -0.011)), depression (bootstrap 95% CI (-0.082; -0.004)), and mindfulness (bootstrap 95% CI (-0.082; -0.002)), significantly mediated the intervention effect on fatigue severity, whereas sleep quality (bootstrap 95% CI (-0.081; 0.009)), sleep disturbance (bootstrap 95% CI (-0.038; 0.029)), and physical activity (bootstrap 95% CI (-0.068; 0.000)) did not. Similar associations were found for fatigue interference.

conclusionsUntire app access reduces fatigue severity and interference mainly by decreasing fatigue catastrophizing, depression, and by increasing mindfulness. Supporting these psychological mechanisms is crucial for reducing fatigue among cancer patients and survivors.

Indexed as

MindfulnessMobile ApplicationsNeoplasmsFatigueHumansMediation Analysisfatiguelongitudinal mediationmHealthmindfulnessphysical activityrandomized controlled trial

Identifiers

PMID35060222
PMCPMC9303515
OpenAlexW4205474176

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.