ArticleJournal of clinical laboratory analysis2022
Hsa_circ_0050102 regulates the pancreatic cancer development via miR-218-5p/PPME1 axis.
Article in Journal of clinical laboratory analysis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed, 7 citations in OpenAlex.
- Circular RNA hsa_circ_0003472 Promotes Pancreatic Ductal Adenocarcinoma Progression and Gemcitabine Resistance Via the mir-1253/ERCC1 Axis.Biological procedures online · 2026Article
- The value of Protein Phosphatase Methylesterase 1 in diagnosis, prognosis and immunoregulation: from pan-cancer analysis to breast cancer verification.Frontiers in immunology · 2026Article
- Decoding the pancreatic cancer microenvironment: The multifaceted regulation of microRNAs.Clinical and translational medicine · 2025Review
- Circular RNAs-mediated angiogenesis in human cancers.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2023Review
- Hsa_circ_0050102 regulates the pancreatic cancer development via miR-218-5p/PPME1 axis.Journal of clinical laboratory analysis · 2022Article
- Roles of circular RNAs in the pathogenesis and treatment of pancreatic cancer.Frontiers in cell and developmental biology · 2022Review
- Circular RNA PGPEP1 induces colorectal cancer malignancy and immune escape.Cell cycle (Georgetown, Tex.)Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
backgroundPancreatic cancer (PC) is a malignancy worldwide. Circular RNAs (circRNAs) affects the growth of PC, nonetheless the mechanism is blurry. Here, we reconnoitered the parts of hsa_circ_0050102 in PC.
methodsHsa_circ_0050102, microRNA-218-5p (miR-218-5p) and protein phosphatase methylesterase 1 (PPME1) abundances were indicated by quantitative RT-PCR or Western blot. Moreover, the cell functions were uncovered. Additionally, the relation of miR-218-5p and hsa_circ_0050102 or PPME1 was identified by dual-luciferase reporter assay. Ultimately, the mice teats were utilized to quantity the part of hsa_circ_0050102.
resultsHsa_circ_0050102 and PPME1 contents were increased, and the miR-218-5p was dwindled in PC. Hsa_circ_0050102 lack subdued cell vitality, colony formation, cell migration and invasion, and angiogenesis, but endorsed cell apoptosis in PC cells. Furthermore, miR-218-5p was established to block the development of PC cells via PPME1. Hsa_circ_0050102 bound to miR-218-5p to adjust the content of PPME1.
conclusionHsa_circ_0050102 expedited the expansion of PC through growing PPME1 abundance by adjusting miR-218-5p.
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