Evidence map›Paper›PMID 35060149›Full record

SynthesisJournal of medical virology2022

Lymphadenopathy post-COVID-19 vaccination with increased FDG uptake may be falsely attributed to oncological disorders: A systematic review.

Khalifa Bshesh, Wafa Khan, Ahamed Lazim Vattoth, Emmad Janjua, Areej Nauman, Muna Almasri, Ateeque Mohamed Ali, Vinutha Ramadorai, Beshr Mushannen, Mai AlSubaie and 7 more

Open access · bronzeAbstract readSystematic Review
In one paragraph

Synthesis in Journal of medical virology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 3 pooled it
7.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 36 citations in OpenAlex.

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  18. Imaging of the head and neck during the COVID19 pandemic.Operative techniques in otolaryngology--head and neck surgery · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors at 1 institution in 1 country.

Khalifa BsheshDivision of Medical Education, Weill Cornell Medicine-Qatar, Qatar Foundation, Education City, Doha, Qatar.
Wafa KhanDivision of Medical Education, Weill Cornell Medicine-Qatar, Qatar Foundation, Education City, Doha, Qatar.
Ahamed Lazim VattothDivision of Medical Education, Weill Cornell Medicine-Qatar, Qatar Foundation, Education City, Doha, Qatar.
Emmad JanjuaDivision of Medical Education, Weill Cornell Medicine-Qatar, Qatar Foundation, Education City, Doha, Qatar.
Areej NaumanDivision of Medical Education, Weill Cornell Medicine-Qatar, Qatar Foundation, Education City, Doha, Qatar.
Muna AlmasriDivision of Medical Education, Weill Cornell Medicine-Qatar, Qatar Foundation, Education City, Doha, Qatar.
Ateeque Mohamed AliDivision of Medical Education, Weill Cornell Medicine-Qatar, Qatar Foundation, Education City, Doha, Qatar.ORCID https://orcid.org/0000-0002-8836-9448
Vinutha RamadoraiDivision of Medical Education, Weill Cornell Medicine-Qatar, Qatar Foundation, Education City, Doha, Qatar.
Beshr MushannenDivision of Medical Education, Weill Cornell Medicine-Qatar, Qatar Foundation, Education City, Doha, Qatar.
Mai AlSubaieDivision of Medical Education, Weill Cornell Medicine-Qatar, Qatar Foundation, Education City, Doha, Qatar.
Ibrahim MohammedDivision of Medical Education, Weill Cornell Medicine-Qatar, Qatar Foundation, Education City, Doha, Qatar.
Mais HammoudDivision of Medical Education, Weill Cornell Medicine-Qatar, Qatar Foundation, Education City, Doha, Qatar.
Pradipta PaulDivision of Medical Education, Weill Cornell Medicine-Qatar, Qatar Foundation, Education City, Doha, Qatar.ORCID https://orcid.org/0000-0001-6283-1596
Haya AlkaabiDivision of Medical Education, Weill Cornell Medicine-Qatar, Qatar Foundation, Education City, Doha, Qatar.
Aliyaa HajiDivision of Medical Education, Weill Cornell Medicine-Qatar, Qatar Foundation, Education City, Doha, Qatar.
Sa'ad LawsDistributed eLibrary, Weill Cornell Medicine-Qatar, Qatar Foundation, Education City, Doha, Qatar.
Dalia ZakariaDivision of Premedical Education, Weill Cornell Medicine-Qatar, Qatar Foundation, Education City, Doha, Qatar.ORCID https://orcid.org/0000-0001-9020-0038
Weill Cornell Medical College in Qatar · QA

Funding

None
6 · The paper itself

Abstract

Coronavirus disease 2019 (COVID-19) has caused a global pandemic that continues to cause numerous deaths to date. Four vaccines have been approved by the Food and Drug Administration as of July 2021 to prevent the transmission of COVID-19: Pfizer, Moderna, AstraZeneca, and Janssen. These vaccines have shown great efficacy and safety profile. One side effect that has been widely reported is post-COVID-19 vaccination lymphadenopathy. Due to the mimicry of the lymphadenopathy for metastases in some oncologic patients, there have been reports of patients who underwent biopsies that showed pathologic confirmation of benign reactive lymphadenopathy secondary to the COVID-19 vaccine. Therefore, understanding the incidence of lymphadenopathy post-COVID-19 vaccinations will help guide radiologists and oncologists in their management of patients, both present oncologic patients, and patients with concerns over their newly presenting lymphadenopathy. A systematic literature search was performed using several databases to identify relevant studies that reported lymphadenopathy post-COVID-19 vaccination. Our results revealed that several cases have been detected in patients undergoing follow-up fluorodeoxyglucose (FDG)-positron emission tomography-computerized tomography scans where lymph nodes ipsilateral to the vaccine injection site show increased uptake of FDG. Thus, knowledge of the incidence of lymphadenopathy may help avoid unnecessary biopsies, interventions, and changes in management for patients, especially oncologic patients who are at risk for malignancies.

Indexed as

COVID-19LymphadenopathyCOVID-19 VaccinesFluorodeoxyglucose F18HumansPositron Emission Tomography Computed TomographySARS-CoV-2United StatesVaccinationCOVID-19 VaccinesFluorodeoxyglucose F18AztraZenecacoronavirusCOVID-19COVID-19 vacccinefluorodeoxyglucose (FDG) PET-CT scanJanssenlymphadenopathyModernaPfizer

Identifiers

PMID35060149
PMCPMC9015520
OpenAlexW4205596033

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.