Evidence map›Paper›PMID 35060132›Full record

ArticleJournal of medical virology2022

Human papillomavirus genotype concordance between Anyplex II HPV28 and linear array HPV genotyping test in anogenital samples.

François Coutlée, Alexandra de Pokomandy, Ann N Burchell, Mariam El-Zein, Marie-Hélène Mayrand, Sophie Rodrigues-Coutlée, Deborah Money, Émilie Comète, Elisabeth McClymont, Danielle Rouleau and 1 more

Open access · greenAbstract read
In one paragraph

Article in Journal of medical virology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 14 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

François CoutléeLaboratoire de Virologie Moléculaire, Centre de recherche du Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada.ORCID 0000-0002-2025-8928
Alexandra de PokomandyDepartment of Family Medicine, McGill University, Montreal, Quebec, Canada.
Ann N BurchellDepartment of Family and Community Medicine, and Centre for Urban Health Solutions, Li Ka Shing Knowledge Institute, St. Michael's Hospital, Unity Health Toronto, Toronto, Ontario, Canada.
Mariam El-ZeinDivision of Cancer Epidemiology, McGill University, Montreal, Quebec, Canada.
Marie-Hélène MayrandDépartements de Microbiologie, Infectiologie et Immunologie, et de Gynécologie-Obstétrique, Université de Montréal, Montreal, Quebec, Canada.
Sophie Rodrigues-CoutléeLaboratoire de Virologie Moléculaire, Centre de recherche du Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada.
Deborah MoneyDepartment of Obstetrics and Gynecology, University of British Columbia, Vancouver, British Columbia, Canada.
Émilie ComèteLaboratoire de Virologie Moléculaire, Centre de recherche du Centre Hospitalier de l'Université de Montréal, Montreal, Quebec, Canada.
Elisabeth McClymontDepartment of Obstetrics and Gynecology, University of British Columbia, Vancouver, British Columbia, Canada.
Danielle RouleauDépartements de Microbiologie, Infectiologie et Immunologie, et de Gynécologie-Obstétrique, Université de Montréal, Montreal, Quebec, Canada.
Eduardo L FrancoDivision of Cancer Epidemiology, McGill University, Montreal, Quebec, Canada.
Centre Hospitalier de l’Université de Montréal · CAMcGill University · CAUniversity of British Columbia · CAMcGill University Health Centre · CASt. Michael's Hospital · CA

Funding

HITCH: A Study of HPV Transmission in Young CouplesR01AI073889 · NIAID · MCGILL UNIVERSITY · PI FRANCO, EDUARDO L. · 2010 to 2013
$419k
NIAID NIH HHS R01 AI073889
6 · The paper itself

Abstract

Anyplex II HPV-28 (HPV-28) can detect individually 28 HPV genotypes. We assessed the agreement between linear array HPV genotyping (LA-HPV) and HPV-28 for detection of 27 HPV genotypes in 410 stored anogenital samples (75 anal samples, 335 physician-collected cervical samples) collected over 5 years from 410 individuals (13 men, 397 women), including 202 HIV-seropositive individuals. HPV DNA was detected in 393 (95.9%, 95% confidence interval [CI]: 93.4-97.4) and 382 (93.2%, 95% CI: 90.3-95.3) samples with HPV-28 and LA-HPV (p = 0.13), respectively, for a good agreement of 96.3% (κ = 0.65). Of the 10503 HPV typing results, 10195 (780 positive, 9577 negative) were concordant, for an agreement of 97.1% (95% CI: 96.7-97.4) and an excellent of κ = 0.82 (95% CI: 0.80-0.84). The mean type-specific concordance for 27 genotypes was 97.0%, 95% CI: 95.8-98.5 (κ = 0.86 ± 0.07, 95% CI: 0.83-0.88). Excellent agreement was obtained individually for all high-risk genotypes (κ = 0.81-0.97) and for most other genotypes except for types 42, 44, 54, 68, and 69. The mean number of types per sample in discordant samples detected with LA-HPV (3.0, 95% CI: 2.7-3.4) was greater than in concordant samples (1.4, 95% CI: 1.3-1.5; p< 0.001). In conclusion, HPV-28 compared favorably with LA-HPV, but was more frequently positive for HPV42 and HPV68.

Indexed as

AlphapapillomavirusPapillomavirus InfectionsCervix UteriDNA, ViralFemaleGenotypeHumansMalePapillomaviridaeSensitivity and SpecificityDNA, Viralconsensus PCRgenital cancergenotypingHPVPCR

Identifiers

PMID35060132
PMCPMC9126003
OpenAlexW4205723176

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.