Evidence map›Paper›PMID 35060072›Full record

ArticleHuman cell2022

Differential microRNA expression profile in blood of children with Down syndrome suggests a role in immunological dysfunction.

Joice Matos Biselli, Bruna Lancia Zampieri, Patrícia Matos Biselli-Chicote, Jorge Estefano Santana de Souza, Matheus Carvalho Bürger, Wilson Araújo da Silva, Eny Maria Goloni-Bertollo, Érika Cristina Pavarino

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In one paragraph

Article in Human cell, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Joice Matos BiselliDepartment of Molecular Biology, Faculdade de Medicina de São José Do Rio Preto , Genetics and Molecular Biology Research Unit (UPGEM), São José Do Rio Preto Medical School (FAMERP), Avenida Brigadeiro Faria Lima, nº 5416 - UPGEM/Bloco U-6, CEP: 15.090-000, São José Do Rio Preto, São Paulo, Brazil.
Bruna Lancia ZampieriDepartment of Molecular Biology, Faculdade de Medicina de São José Do Rio Preto , Genetics and Molecular Biology Research Unit (UPGEM), São José Do Rio Preto Medical School (FAMERP), Avenida Brigadeiro Faria Lima, nº 5416 - UPGEM/Bloco U-6, CEP: 15.090-000, São José Do Rio Preto, São Paulo, Brazil.
Patrícia Matos Biselli-ChicoteDepartment of Molecular Biology, Faculdade de Medicina de São José Do Rio Preto , Genetics and Molecular Biology Research Unit (UPGEM), São José Do Rio Preto Medical School (FAMERP), Avenida Brigadeiro Faria Lima, nº 5416 - UPGEM/Bloco U-6, CEP: 15.090-000, São José Do Rio Preto, São Paulo, Brazil.
Jorge Estefano Santana de SouzaDepartment of Genetics, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.
Matheus Carvalho BürgerDepartment of Genetics, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.
Wilson Araújo da SilvaDepartment of Genetics, Ribeirão Preto Medical School, University of São Paulo, São Paulo, Brazil.
Eny Maria Goloni-BertolloDepartment of Molecular Biology, Faculdade de Medicina de São José Do Rio Preto , Genetics and Molecular Biology Research Unit (UPGEM), São José Do Rio Preto Medical School (FAMERP), Avenida Brigadeiro Faria Lima, nº 5416 - UPGEM/Bloco U-6, CEP: 15.090-000, São José Do Rio Preto, São Paulo, Brazil.
Érika Cristina PavarinoDepartment of Molecular Biology, Faculdade de Medicina de São José Do Rio Preto , Genetics and Molecular Biology Research Unit (UPGEM), São José Do Rio Preto Medical School (FAMERP), Avenida Brigadeiro Faria Lima, nº 5416 - UPGEM/Bloco U-6, CEP: 15.090-000, São José Do Rio Preto, São Paulo, Brazil. erika@famerp.br.

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 305641/2011-5Fundação de Amparo à Pesquisa do Estado de São Paulo 2010/ 00153-3
6 · The paper itself

Abstract

Down syndrome (DS), caused by trisomy of chromosome 21 (HSA21), results in a broad range of phenotypes. However, the determinants contributing to the complex and variable phenotypic expression of DS are still not fully known. Changes in microRNAs (miRNAs), short non-coding RNA molecules that regulate gene expression post-transcriptionally, have been associated with some DS phenotypes. Here, we investigated the genome-wide mature miRNA expression profile in peripheral blood mononuclear cells (PBMCs) of children with DS and controls and identified biological processes and pathways relevant to the DS pathogenesis. The expression of 754 mature miRNAs was profiled in PBMCs from six children with DS and six controls by RT-qPCR using TaqMan

Indexed as

Down SyndromeMicroRNAsGene Expression ProfilingHumansLeukocytes, MononuclearSignal TransductionMicroRNAsMIRN942 microRNA, humanBlood mononuclear cellsDown syndromeImmune systemmicroRNA expressionTrisomy 21

Identifiers

PMID35060072
PMCPMC8773395

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.