Evidence map›Paper›PMID 35059981›Full record

ArticleBiological trace element research2022

Resveratrol-Selenium Nanoparticles Alleviate Neuroinflammation and Neurotoxicity in a Rat Model of Alzheimer's Disease by Regulating Sirt1/miRNA-134/GSK3β Expression.

Omayma A R Abozaid, Mohsen W Sallam, Sawsan El-Sonbaty, Samy Aziza, Basma Emad, Esraa S A Ahmed

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Article in Biological trace element research, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 2 pooled it
12.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

60 citing papers in PubMed, 2 syntheses or guidelines pooled it, 96 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Omayma A R AbozaidBiochemistry Department, Faculty of Veterinary Medicine, Benha University, Benha, Egypt.ORCID https://orcid.org/0000-0002-1752-6709
Mohsen W SallamBiochemistry Department, Faculty of Veterinary Medicine, Benha University, Benha, Egypt.
Sawsan El-SonbatyNational Center for Radiation Research and Technology, Atomic Energy Authority, Cairo, Egypt.
Samy AzizaBiochemistry Department, Faculty of Veterinary Medicine, Benha University, Benha, Egypt.
Basma EmadAnatomy and Embryology Department, Faculty of Medicine, Cairo University, Cairo, Egypt.
Esraa S A AhmedRadiation Biology, National Center for Radiation Research and Technology, Atomic Energy Authority, Nasr City, Cairo, 11787, Egypt. esraa.tamim@yahoo.com.ORCID https://orcid.org/0000-0001-5358-4394
Benha University · EGEgyptian Atomic Energy Authority · EGCairo University · EG

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Alzheimer's disease (AD) is a brain disorder associated with a gradual weakening in neurocognitive functions, neuroinflammation, and impaired signaling pathways. Resveratrol (RSV) has neuroprotective properties, but with low bioavailability, and low solubility in vivo. Selenium (Se) is an essential micronutrient for brain function. Thus, this study aimed to evaluate the role of formulated RSV-Se nanoparticles (RSV-SeNPs) on neurochemical and histopathological approaches associated with the AD model in rats induced by Aluminum chloride (AlCl

Indexed as

Alzheimer DiseaseMicroRNAsNanoparticlesNeurotoxicity SyndromesSeleniumAluminum ChlorideAmyloid beta-PeptidesAnimalsAnti-Inflammatory AgentsAntioxidantsCholinergic AgentsGlycogen Synthase Kinase 3 betaInterleukin-1betaMicronutrientsNeuroinflammatory DiseasesPhosphatidylinositol 3-KinasesAluminum ChlorideAmyloid beta-PeptidesAnti-Inflammatory AgentsAntioxidantsCholinergic AgentsGlycogen Synthase Kinase 3 betaInterleukin-1betaMicronutrientsMicroRNAsMIRN134 microRNA, ratPhosphatidylinositol 3-KinasesResveratrolSeleniumSirt1 protein, ratSirtuin 1Aluminum, Alzheimer’s diseasemiR-134NeuroinflammationNeurotoxicityResveratrolSeleniumSIRT1

Identifiers

PMID35059981
OpenAlexW4205392261

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.