ArticleClinical autonomic research : official journal of the Clinical Autonomic Research Society2022
Resting-state functional magnetic resonance imaging in patients with Parkinson's disease with and without constipation: a prospective study.
Article in Clinical autonomic research : official journal of the Clinical Autonomic Research Society, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 12 citations in OpenAlex.
- Constipation Is Linked to Neuroinflammation in Early Parkinson's Disease.Movement disorders : official journal of the Movement Disorder Society · 2026Article
- Distinct brain activation patterns linked to clinical symptoms during hand grasping in Parkinson's disease.Frontiers in aging neuroscience · 2026Article
- Feasibility study of differentiating patients with levodopa-induced dyskinesia using cerebellar gray and white matter radiomics features from 3DT1WI images.Frontiers in aging neuroscience · 2026Article
- Analysis of parkinson's disease patients with Gastrointestinal symptoms using structural and functional magnetic resonance imaging.Brain imaging and behavior · 2025Article
- Neuroanatomy and Functional Connectivity in Patients with Parkinson's Disease with or without Restless Legs Syndrome.Neurology and therapy · 2022Article
- Differences in Brain Activity Between Dopa-Responsive and -Unresponsive Pain in Parkinson's Disease.Pain and therapy · 2022Article
- Functional brain neuroimaging as a tool to study gastrointestinal manifestations in patients with Parkinson's disease.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2022Article
- Interactions between gut microbiota and Parkinson's disease: The role of microbiota-derived amino acid metabolism.Frontiers in aging neuroscience · 2022Review
- Correlation of matrix metalloproteinase 3 and matrix metalloproteinase 9 levels with non-motor symptoms in patients with Parkinson's disease.Frontiers in aging neuroscience · 2022Article
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8 authors at 1 institution in 1 country.
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Abstract
purposeThe etiology of constipation in Parkinson's disease is largely unknown. The aim of this study was to explore changes in regional neural activity and functional connections associated with constipation in a large cohort of individuals with Parkinson's disease.
methodsWe prospectively recruited 106 patients with Parkinson's disease with constipation and 73 patients with Parkinson's disease without constipation. We used resting-state functional magnetic resonance imaging for the first time to measure differences in regional neural activity and functional connections between the two patient groups.
resultsPatients with constipation showed significantly higher amplitude of low-frequency fluctuation than patients without constipation in the right dorsal pons extending into the cerebellum and in the right insula. The two types of patients also showed substantial differences in functional connections linking the superior temporal gyrus, particularly the right superior temporal gyrus, with multiple brain regions.
conclusionRegional neural activity and functional connectivity in the brain differ substantially between patients with Parkinson's disease with or without constipation. These findings provide a foundation for understanding the pathophysiology of constipation in Parkinson's disease and for identifying therapeutic targets.
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