ArticleOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2022
Age-related reference data of bone microarchitecture, volumetric bone density, and bone strength parameters in a population of healthy Brazilian men: an HR-pQCT study.
Article in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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9 citing papers in PubMed, 12 citations in OpenAlex.
- High-resolution peripheral quantitative computed tomography imaging and bone biomarker characteristics of patients with ischemic stroke or transient ischemic attack-baseline analysis of the Post-stroke Osteopathy study.Archives of osteoporosis · 2026Article
- Longitudinal bone loss in patients with stage 3 CKD: a study based on densitometry and HR-pQCT.Archives of osteoporosis · 2026Article
- Digital tomosynthesis derived textural and geometric measures of vertebral bone quality in postmenopausal women with primary hyperparathyroidism.Journal of endocrinological investigation · 2026Article
- Subclinically low BMD in young men is associated with compromised bone microarchitecture and lower lean mass.Journal of the Endocrine Society · 2026Article
- Age-Related Differences in Root Migration and Lesion Formation After Third-Molar Coronectomy.Medical science monitor : international medical journal of experimental and clinical research · 2025Article
- Ageing-related bone and immunity changes: insights into the complex interplay between the skeleton and the immune system.Bone research · 2024Review
- Impaired bone mineral density and microarchitecture in female adolescents with IgE-mediated cow's milk allergy.Archives of osteoporosis · 2024Observational
- TBS correlates with bone density and microstructure at trabecular and cortical bone evaluated by HR-pQCT.Journal of bone and mineral metabolism · 2024Article
- Assessment of Bone Microarchitecture in Patients with Systemic Mastocytosis and its Association with Clinical and Biochemical Parameters of the Disease.Calcified tissue international · 2023Article
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Abstract
In a cross-sectional cohort of 340 healthy Brazilian men aged 20 to 92 years, data on density, structure, and strength of the distal radius and tibia were obtained using high-resolution peripheral quantitative computed tomography (HR-pQCT) to develop age- and site-specific reference curves. Age-dependent changes differed between the sites and bone compartments (trabecular and cortical).
introductionThe aim of this study was to establish age-related reference curves for bone densities, microarchitectural properties, and estimated failure load measured by HR-pQCT (distal radius and tibia) in men. Also, to correlate bone stiffness with the other HR-pQCT parameters, areal bone mineral density (BMD) by DXA and trabecular bone score (TBS).
methodsHealthy Brazilian men (n = 340) between the ages of 20 and 92 years were recruited. Non-dominant radius and left tibia were scanned using HR-pQCT (Xtreme CT I). Standard and automated segmentation methods were performed, and bone strength estimated by FE analysis. Bone mineral density at lumbar spine, total hip, femoral neck, and TBS were measured using DXA (Hologic, QDR4500).
resultsAge-related reference curves were constructed at the distal radius and tibia for volumetric bone density, morphometry, and estimated bone strength parameters. There was a linear relationship with age only for thickness measurements of distal radius (trabecular: R
conclusionThe current study expands the HR-pQCT worldwide database and presents an adequate methodology for the construction of reference data in other populations. Moreover, the correlation of bone strength estimated by FEA with other bone microstructural parameters provided by HR-pQCT helps to determine the contribution of each of these variables to fracture risk prediction in men.
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