ArticleEClinicalMedicine2022
A new validated screening method for endometriosis diagnosis based on patient questionnaires.
Article in EClinicalMedicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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26 citing papers in PubMed, 64 citations in OpenAlex.
- Central sensitization in patients with chronic pelvic pain resistant to hormonal therapy: A cross-sectional study of prevalence and clinical correlates in a tertiary referral cohort.Acta obstetricia et gynecologica Scandinavica · 2026Article
- Interpretable machine learning for endometriosis classification: a rule-based approach.BMC medical informatics and decision making · 2026Article
- Time to Diagnose for Adolescent Endometriosis in West Java, Indonesia Population: A Single Centre 2 Years Retrospective Descriptive Study.International journal of women's health · 2026Article
- Diagnostic discrepancies and clinical value of second medical opinions (SMO) for endometriosis: a nationwide study analysis.BMC women's health · 2025Observational
- Urogynecologic Symptoms Are Not Specific to Anatomic Region of Digestive Symptoms.Neurogastroenterology and motility · 2025Article
- Exploring the Early Endometrial-Blastocyst Interactome in Endometriosis: An Integrative Study.Biomedicines · 2025Article
- Article
- Utilizing Artificial Intelligence: Machine Learning Algorithms to Develop a Preoperative Endometriosis Prediction Model.Journal of minimally invasive gynecology · 2025Article
- Screening for endometriosis: A scoping review of screening measures that could support early diagnosis.BMC women's health · 2025Article
- The Hôtel-Dieu MRI Classification of Uterosacral Ligament Involvement in Endometriosis: A Pictorial Guide to Clinical Use.Diagnostics (Basel, Switzerland) · 2025Review
- Study on the relationship between the non-HDL/HDL cholesterol ratio (NHHR) and endometriosis: a cross-sectional analysis utilizing the NHANES dataset.Lipids in health and disease · 2025Article
- Association between the C-reactive protein-triglyceride-glucose index and endometriosis: a cross-sectional study using data from the national health and nutrition examination survey, 1996-2006.BMC women's health · 2025Article
- Effects of dysmenorrhea on work productivity and quality of life in Japanese women: A large-scale web-based cross-sectional study.PloS one · 2025Article
- Single-Cell RNA Sequencing of PBMCs Identified Junction Plakoglobin (JUP) as Stratification Biomarker for Endometriosis.International journal of molecular sciences · 2024Article
- Artificial Intelligence, Clinical Decision Support Algorithms, Mathematical Models, Calculators Applications in Infertility: Systematic Review and Hands-On Digital Applications.Mayo Clinic proceedings. Digital health · 2024Review
- Management of patients with endometriosis and infertility: laparoscopic treatment and spontaneous pregnancy rate.JBRA assisted reproduction · 2024Article
- Relationship between triglyceride-glucose index and endometriosis: a cross-sectional analysis.BMC women's health · 2024Article
- An accessible, non-invasive tool for endometriosis diagnosis reveals an association between age at symptom onset and endometriosis symptom prevalence.Journal of endometriosis and pelvic pain disorders · 2024Article
- MRI classification of uterosacral ligament involvement in endometriosis: the Hôtel-Dieu classification.The British journal of radiology · 2024Article
- Association between Endometriosis and the Risk of Ovarian, Endometrial, Cervical, and Breast Cancer: A Population-Based Study from the U.S. National Inpatient Sample 2016-2019.Current oncology (Toronto, Ont.) · 2024Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe time between symptoms onset and endometriosis diagnosis is usually long. The negative impacts of delayed endometriosis diagnosis can affect patients and health outcomes.
methodsWe conducted a case-control study using clinical symptoms and epidemiological data extracted from a prospective pre-operative patient questionnaire compared between patients with histologically proven endometriosis and patients with no endometriosis at surgical exploration from 2005 to 2018, in a French referral center. We used the beta coefficients of the significant variables introduced in a multiple regression model to devise a score (score 1), evaluated by the area under the curve (or C-index), with three levels, defined by a score between 1 and ≥ 25: (i) highly specific, identifying correctly the patients without the disease; (ii) highly sensitive, identifying the patients with the disease; and (iii) a level maximizing sensitivity and specificity for the best classification of the whole population. To minimize patient self-evaluation of pain, we devised a second score (score 2) with the same method and levels and scores definition, excluding visual analog scale pain scores, except for dysmenorrhea. These scores were validated on an internal and external population.
findingsScore 1 had a C-index of 0.81 (95% CI [0.79-0.83]). Results for the three score 1 levels were: ≥ 25: specificity of 91% (95% CI [89-93]); < 11: sensitivity of 91% (95% CI [89-93]); ≥ 18: specificity of 75% (95% CI [72-78]) and sensitivity of 73% (95% CI [70-76]). Score 2 had a C-index of 0.75 (95% CI [73-77]). The three levels of score 2 were: ≥ 24: specificity of 82% (95% CI [80-85]); < 7: sensitivity of 92% (95% CI [90-94]); ≥ 17: specificity of 62% (95% CI [58-65]) and sensitivity of 78% (95% CI [75-81]). The two scores were internally and externally validated.
interpretationA score based only on a patient questionnaire could allow identification of a population at high risk of endometriosis. This strategy might help referral to specialized radiologists for a non-surgical endometriosis scan.
fundingNone.
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