ArticleBeyoglu eye journal2021
Is There a Relationship between Statin Use and Corneal Specular Microscopy and Topography Findings?
Article in Beyoglu eye journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed, 2 citations in OpenAlex.
- Rutin-Activated Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) Attenuates Corneal and Heart Damage in Mice.Pharmaceuticals (Basel, Switzerland) · 2024Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesInformation about the possible effect of statins on the human corneal endothelium is still not clear. This study was the first known investigation of the influence of statins on corneal specular microscopy (SM) and topography parameters.
methodsThirty-four patients using a statin (atorvastatin) as hyperlipidemia treatment (Group 1) and 34 age- and sex-matched healthy subjects (Group 2) were prospectively included in the study. Demographic data and ophthalmic findings of participants were reported and analyzed. Cellular morphology was evaluated using the noncontact SM and corneal endothelial cell density (CECD) (cells/mm
resultsThe mean age was 53.03±7.23 years (range: 38-73 years) for Group 1 and 53.15±10.7 years (range: 34-80 years) for Group 2 (p=0.958). Group 1 consisted of 11 female and 23 male patients and Group 2 included 13 female and 21 male participants (p=0.798). The mean CECD density was significantly higher in Group 1 when compared with that of Group 2 (2544.34±244.76 cells/mm
conclusionThe findings of this study revealed higher CECD values in statin users. Statins may have beneficial effects on cornea morphology.
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Registered trials
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