ArticleIEEE transactions on radiation and plasma medical sciences2021
Improvement of Spatial Resolution with Iterative PET Reconstruction using UltraFast TOF.
Article in IEEE transactions on radiation and plasma medical sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Clinical added value of LAFOV PET/CT in patients undergoing same-day [18 F]FDG SAFOV PET/CT scans: an initial experience report and explorative study.European journal of nuclear medicine and molecular imaging · 2026Article
- Time-of-Flight Requirements to Mitigate Blurring Induced by Annihilation Photon Acollinearity.IEEE transactions on radiation and plasma medical sciences · 2026Article
- Biodistribution studies ofApplied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine · 2025Article
- Impact of 18F-choline PET-CT or PET-MRI on surgical strategy in patients with primary hyperparathyroidism.BJS open · 2025Article
- Multi-angle acquisition and 3D composite reconstruction for organ-targeted PET using planar detectors.Medical physics · 2025Article
- Monte Carlo methods for medical imaging research.Biomedical engineering letters · 2024Review
- On the implementation of acollinearity in PET Monte Carlo simulations.Physics in medicine and biology · 2024Article
- Image Reconstruction Analysis for Positron Emission Tomography With Heterostructured Scintillators.IEEE transactions on radiation and plasma medical sciences · 2023Article
- Reconstruction-free positron emission imaging: Fact or fiction?Frontiers in nuclear medicine · 2022Article
- Time of Flight in Perspective: Instrumental and Computational Aspects of Time Resolution in Positron Emission Tomography.IEEE transactions on radiation and plasma medical sciences · 2021Article
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
The impact of Time-of-Flight (TOF) on positron emission tomography (PET) spatial resolution is generally considered negligible. In this work, a two-step approach based on simulations of two-dimensional scanner configurations is taken to show that ultra-fast TOF has the potential to overcome the limitation induced by the physical size of detectors on spatial resolution. An estimation of the lower bound on spatial resolution using point sources is provided, followed by a qualitative assessment of the resolution obtained using a Hot Spot phantom. The impact of detector width, TOF resolution and TOF binning on the achieved spatial resolution is also studied. While gain beyond the expected blur due to detector size is demonstrated, the detector size remains one limiting factor albeit less prominent. The dependence on acquisition statistics to reach the full potential of TOF-induced gain in spatial resolution is demonstrated. A simulated brain phantom acquired with a fictive three-dimensional PET scanner was qualitatively analyzed and structures smaller than the typical limit are clearly made visible by reconstructing the images with a ∼13-ps TOF resolution. A potential application of this feature of ultra-fast TOF would be the design of clinical PET scanners achieving spatial resolution beyond the current state-of-the-art.
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