Evidence map›Paper›PMID 35059526›Full record

ArticleHeliyon2022

Assessment of androgen receptor, IGF-IR and insulin receptor expression in male patients with severe peripheral artery disease.

Michele Andreucci, Damiano Cosimo Rigiracciolo, Umberto Marcello Bracale, Nicola Ielapi, Michele Provenzano, Diletta D'Iuorno, Ashour Michael, Pasquale Mastroroberto, Giuseppe Filiberto Serraino, Marcello Maggiolini and 1 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Michele AndreucciDepartment of Health Sciences, Nephrology Unit, University of Catanzaro, I-88100, Catanzaro, Italy.
Damiano Cosimo RigiraccioloDepartment of Pharmacy and Health and Nutrition Sciences, University of Calabria, I-87036, Rende CS, Italy.
Umberto Marcello BracaleDepartment of Public Health, Vascular Surgery Unit, University of Naples "Federico II", I-80126, Naples, Italy.
Nicola IelapiSapienza" University of Rome, Department of Public Health and Infectious Disease, I-00185 Roma, Italy.
Michele ProvenzanoDepartment of Medical and Surgical Sciences, University of Catanzaro, I-88100, Catanzaro, Italy.
Diletta D'IuornoDepartment of Medical and Surgical Sciences, University of Catanzaro, I-88100, Catanzaro, Italy.
Ashour MichaelDepartment of Health Sciences, Nephrology Unit, University of Catanzaro, I-88100, Catanzaro, Italy.
Pasquale MastrorobertoDepartment of Experimental and Clinical Medicine, University of Catanzaro, I-88100, Catanzaro, Italy.
Giuseppe Filiberto SerrainoDepartment of Experimental and Clinical Medicine, University of Catanzaro, I-88100, Catanzaro, Italy.
Marcello MaggioliniDepartment of Pharmacy and Health and Nutrition Sciences, University of Calabria, I-87036, Rende CS, Italy.
Raffaele SerraInteruniversity Center of Phlebolymphology (CIFL), International Research and Educational Program in Clinical and Experimental Biotechnology" at the Department of Surgical and Medical Sciences University Magna Graecia of Catanzaro, I-88100 Catanzaro, Italy.
Magna Graecia University · ITUniversity of Calabria · ITUniversity of Naples Federico II · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPeripheral artery disease (PAD) of the lower limbs is a common condition that can affect quality of life. Androgen receptor (AR) can exert sex-specific effects on metabolic system, endothelial function and vascular tone. IGF-I receptor (IGF-IR) and insulin receptor (IR) may also be involved in the aforementioned functions. The aim of this study was to evaluate AR, IGF-IR and IR expression in the arterial vessel walls of PAD patients.

resultsThis is a cross-sectional study examining 30 males with PAD undergoing open surgery procedures. Mean age was 75.9 ± 8.8y. All patients belonged to Rutherford stage 4-6. Median expression levels of IR, IGF-IR and AR significantly decreased from stage 4-6 (p < 0.05). SIGNIFICANCE: The study evidenced a progressive decrease of IR, IGF-IR and AR expression as the severity of disease increased. Altered levels of IR, IGF-IR and AR following PAD may be useful for the clinical evaluation of these patients.

Indexed as

Androgen receptorARIGF-IRIGF-I receptorInsulin receptorIRPADPeripheral artery disease

Identifiers

PMID35059526
PMCPMC8760540
OpenAlexW4206652020

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.