ArticleInternational journal of cardiology. Heart & vasculature2022
No-reflow phenomenon and in vivo cholesterol crystals combined with lipid core in acute myocardial infarction.
Article in International journal of cardiology. Heart & vasculature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 15 citations in OpenAlex.
- Intravascular Imaging to Predict the Coronary No-Reflow and Slow-Flow Phenomena: Advances and Perspectives.Reviews in cardiovascular medicine · 2026Review
- Long Inflation at Stent Deployment in Intravascular Ultrasound-Guided Percutaneous Coronary Intervention for Acute Myocardial Infarction.Circulation reports · 2025Article
- Modern Imaging Techniques for Percutaneous Coronary Intervention Guidance: A Focus on Intravascular Ultrasound and Optical Coherence Tomography.Journal of clinical medicine · 2025Review
- The formation of cholesterol crystals and embolization during myocardial infarction.American heart journal plus : cardiology research and practice · 2025Article
- Evaluating the Influence of Morphological Features on the Vulnerability of Lipid-Rich Plaques During Stenting.Journal of biomechanical engineering · 2025Article
- Recent highlights from theInternational journal of cardiology. Heart & vasculature · 2024Article
- Recent highlights from theInternational journal of cardiology. Heart & vasculature · 2024Article
- Meta-analysis of the correlation between inflammatory response indices and no-reflow after PCI in patients with acute STEMI.American journal of translational research · 2024Review
- Predictive value of the triglyceride-glucose index for no-reflow phenomenon after percutaneous coronary intervention in patients with acute ST-segment elevation myocardial infarction complicated by metabolic syndrome.American journal of translational research · 2024Article
- Coronary No-Reflow after Primary Percutaneous Coronary Intervention-Current Knowledge on Pathophysiology, Diagnosis, Clinical Impact and Therapy.Journal of clinical medicine · 2023Review
- Which is more useful for predicting no-reflow phenomenon? Insights from optical coherence tomography and coronary computed tomography.Cardiovascular intervention and therapeutics · 2023Article
- Lipidomic Predictors of Coronary No-Reflow.Metabolites · 2023Article
- A Narrative Review of the Classical and Modern Diagnostic Methods of the No-Reflow Phenomenon.Diagnostics (Basel, Switzerland) · 2022Review
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe release of lipid-laden plaque material subsequent to ST-segment elevation myocardial infarction (STEMI) may contribute to the no-reflow phenomenon. The aim of this study was to investigate the association between in vivo cholesterol crystals (CCs) detected by optical coherence tomography (OCT) and the no-reflow phenomenon after successful percutaneous coronary intervention (PCI) in patients with acute STEMI.
methodsWe investigated 182 patients with STEMI. Based on the thrombolysis in myocardial infarction (TIMI) flow grade after PCI, patients were divided into a no-reflow group (n = 31) and a reflow group (n = 151). On OCT, CCs were defined as thin, high-signal intensity regions within a plaque. A multivariable logistic regression analysis was performed to determine predictors for the no-reflow phenomenon.
resultsThe prevalence of CCs was higher in the no-reflow group than the reflow group (no-reflow group, 77% vs. reflow group, 53%; p = 0.012). The multivariable logistic model showed that the CC number, lipid arc and ostial lesions were positive independent predictors of no-reflow. The combination of a lipid arc ≥ 139°and CC number ≥ 12 showed good predictive performance for the no-reflow phenomenon (sensitivity, 48%; specificity, 93%; and accuracy, 86%).
conclusionIn vivo CCs at the culprit plaque are associated with the no-reflow phenomenon after PCI in patients with STEMI. The combination of the number of CCs and lipid arc can predict the no-reflow phenomenon after PCI with a high accuracy of 86%.
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