Evidence map›Paper›PMID 35059473›Full record

ArticleEuropean journal of radiology open2022

Pilar M Ferraro, Cristina Campi, Alberto Miceli, Claudia Rolla-Bigliani, Matteo Bauckneht, Lorenzo Gualco, Michele Piana, Cecilia Marini, Lucio Castellan, Silvia Morbelli and 3 more

Open access · goldAbstract read
In one paragraph

Article in European journal of radiology open, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 1 country.

Pilar M FerraroDepartment of Neuroradiology, IRCCS Ospedale Policlinico San Martino, Largo R. Benzi 10, 16132 Genoa, Italy.
Cristina CampiLISCOMPlab, Department of Mathematics (DIMA), University of Genoa, Via Balbi 5, 16126 Genoa, Italy.
Alberto MiceliNuclear Medicine Unit, IRCCS Ospedale Policlinico San Martino, Largo R. Benzi 10, 16132 Genoa, Italy.
Claudia Rolla-BiglianiDepartment of Neuroradiology, IRCCS Ospedale Policlinico San Martino, Largo R. Benzi 10, 16132 Genoa, Italy.
Matteo BaucknehtNuclear Medicine Unit, IRCCS Ospedale Policlinico San Martino, Largo R. Benzi 10, 16132 Genoa, Italy.
Lorenzo GualcoDepartment of Neuroradiology, IRCCS Ospedale Policlinico San Martino, Largo R. Benzi 10, 16132 Genoa, Italy.
Michele PianaLISCOMPlab, Department of Mathematics (DIMA), University of Genoa, Via Balbi 5, 16126 Genoa, Italy.
Cecilia MariniNuclear Medicine Unit, IRCCS Ospedale Policlinico San Martino, Largo R. Benzi 10, 16132 Genoa, Italy.
Lucio CastellanDepartment of Neuroradiology, IRCCS Ospedale Policlinico San Martino, Largo R. Benzi 10, 16132 Genoa, Italy.
Silvia MorbelliNuclear Medicine Unit, IRCCS Ospedale Policlinico San Martino, Largo R. Benzi 10, 16132 Genoa, Italy.
Claudia CaponnettoDepartment of Neurology, IRCCS Ospedale Policlinico San Martino, Largo R. Benzi 10, 16132 Genoa, Italy.
Gianmario SambucetiNuclear Medicine Unit, IRCCS Ospedale Policlinico San Martino, Largo R. Benzi 10, 16132 Genoa, Italy.
Luca RoccatagliataDepartment of Neuroradiology, IRCCS Ospedale Policlinico San Martino, Largo R. Benzi 10, 16132 Genoa, Italy.
Ospedale Policlinico San Martino · ITUniversity of Genoa · ITInstitute of Molecular Bioimaging and Physiology · ITSuperconducting and other Innovative Materials and Devices Institute · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe partial volume effect (PVE) complicates PET studies of neurodegenerative diseases, since a decreased

methodsPET and MRI data from 15 ALS patients were analyzed using PETSurfer to implement 4 distinct PVC methods: noPVC, Meltzer (MZ), Müller-Gärtner (MG) and Symmetric Geometric Transfer Matrix (SGTM). For each method and Region of Interest (ROI), the

resultsMG/SGTM application almost halved the number of regions showing a significant age-related hypometabolism, while the same effect was not observed for disease course, where only the distribution of identified regions varied. Three distinct patterns emerged: regions showing a significant age/disease course-related effect across all the different methods, regions yielding significance only with MG/SGTM application, and regions maintaining significance only with noPVC/MZ application.

conclusionsSignificant changes in the distribution of aging and disease course-related hypometabolism were observed when the effect of the underlying structural status was considered, supporting the need for investigate the impact of PVE on PET-assessed metabolic changes in clinical and research settings.

Indexed as

18F-FDG, 18F Fluorodeoxyglucose18F-FDG positron emission tomographyALS, Amyotrophic Lateral SclerosisAmyotrophic lateral sclerosisCT, Cortical ThicknessMagnetic resonance imagingMG, Müller-GärtnerMZ, MeltzerPartial volume correctionPVC, Partial Volume CorrectionPVE, Partial Volume EffectROI, Region of InterestSGTM, Symmetric Geometric Transfer Matrix

Identifiers

PMID35059473
PMCPMC8760536
OpenAlexW4205448836

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.