Evidence map›Paper›PMID 35059435›Full record

ArticleFrontiers in molecular biosciences2021

Hypermethylated PCDHGB7 as a Biomarker for Early Detection of Endometrial Cancer in Endometrial Brush Samples and Cervical Scrapings.

Jiangjing Yuan, Zhanrui Mao, Qi Lu, Peng Xu, Chengyang Wang, Xiaona Xu, Zhaowei Zhou, Tongsheng Zhang, Wenqiang Yu, Shihua Dong and 2 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in molecular biosciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.9field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 21 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Review
  8. Deregulated methylation and expression ofFrontiers in immunology · 2025
    Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 1 country.

Jiangjing YuanDepartment of Obstetrics and Gynecology, International Peace Maternity and Child Health Hospital, Shanghai Key Laboratory of Embryo Original Diseases, and Institute of Birth Defects and Rare Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhanrui MaoShanghai Epiprobe Biotechnology Co., Ltd, Shanghai, China.
Qi LuDepartment of Obstetrics and Gynecology, Jinshan Hospital of Fudan University, Shanghai, China.
Peng XuShanghai Public Health Clinical Center and Department of General Surgery, Huashan Hospital, Cancer Metastasis Institute and Laboratory of RNA Epigenetics, Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
Chengyang WangShanghai Epiprobe Biotechnology Co., Ltd, Shanghai, China.
Xiaona XuDepartment of Obstetrics and Gynecology, International Peace Maternity and Child Health Hospital, Shanghai Key Laboratory of Embryo Original Diseases, and Institute of Birth Defects and Rare Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Zhaowei ZhouDepartment of Obstetrics and Gynecology, International Peace Maternity and Child Health Hospital, Shanghai Key Laboratory of Embryo Original Diseases, and Institute of Birth Defects and Rare Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Tongsheng ZhangShanghai Public Health Clinical Center and Department of General Surgery, Huashan Hospital, Cancer Metastasis Institute and Laboratory of RNA Epigenetics, Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
Wenqiang YuShanghai Public Health Clinical Center and Department of General Surgery, Huashan Hospital, Cancer Metastasis Institute and Laboratory of RNA Epigenetics, Institutes of Biomedical Sciences, Shanghai Medical College, Fudan University, Shanghai, China.
Shihua DongShanghai Epiprobe Biotechnology Co., Ltd, Shanghai, China.
Yudong WangDepartment of Obstetrics and Gynecology, International Peace Maternity and Child Health Hospital, Shanghai Key Laboratory of Embryo Original Diseases, and Institute of Birth Defects and Rare Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Weiwei ChengDepartment of Obstetrics and Gynecology, International Peace Maternity and Child Health Hospital, Shanghai Key Laboratory of Embryo Original Diseases, and Institute of Birth Defects and Rare Diseases, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
International Peace Maternity & Child Health Hospital · CNHuashan Hospital · CNJinshan Hospital of Fudan University · CNShanghai Jiao Tong University · CNShanghai Public Health Clinical Center · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Endometrial cancer (EC) is one of the most common gynecologic cancers in developed countries. Presently, it is imperative to develop a reliable, noninvasive, or minimally invasive detection method for EC. We explored the possibility of using DNA methylation marker from endometrial brush samples (with a "Tao brush") and cervical scrapes (with a "Pap brush") for early detection of EC. We analyzed the methylation data of EC and normal endometrial tissues from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) data sets. An optimized methylation-sensitive restriction enzyme combined with real-time fluorescent quantitative PCR (MSRE-qPCR) was used for methylation detection. Included in the training set were 143 endometrial tissues, 103 Tao, and 109 Pap brush samples. The validation set included 110 Tao and 112 Pap brush samples.

Indexed as

cervical scrapingsDNA methylation biomarkerendometrial brushendometrial cancerPCDHGB7

Identifiers

PMID35059435
PMCPMC8763697
OpenAlexW4206068663

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.