Evidence map›Paper›PMID 35059390›Full record

ArticleFrontiers in bioengineering and biotechnology2021

Engineering of CYP153A33 With Enhanced Ratio of Hydroxylation to Overoxidation Activity in Whole-Cell Biotransformation of Medium-Chain 1-Alkanols.

Hyuna Park, Doyeong Bak, Wooyoung Jeon, Minjung Jang, Jung-Oh Ahn, Kwon-Young Choi

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in bioengineering and biotechnology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
1.2field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Hyuna ParkDepartment of Environmental Engineering, College of Engineering, Ajou University, Suwon, South Korea.
Doyeong BakDepartment of Environmental and Safety Engineering, College of Engineering, Ajou University, Suwon, South Korea.
Wooyoung JeonBiotechnology Process Engineering Center, Korea Research Institute of Biosceince and Biotechnology (KRIBB), Cheongju, South Korea.
Minjung JangBiotechnology Process Engineering Center, Korea Research Institute of Biosceince and Biotechnology (KRIBB), Cheongju, South Korea.
Jung-Oh AhnBiotechnology Process Engineering Center, Korea Research Institute of Biosceince and Biotechnology (KRIBB), Cheongju, South Korea.
Kwon-Young ChoiDepartment of Environmental Engineering, College of Engineering, Ajou University, Suwon, South Korea.
Ajou University · KRKorea Research Institute of Bioscience and Biotechnology · KRKorea University of Science and Technology · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

α,ω-Dodecanediol is a versatile material that has been widely used not only as an adhesive and crosslinking reagent, but also as a building block in the pharmaceutical and polymer industries. The biosynthesis of α,ω-dodecanediol from fatty derivatives, such as dodecane and dodecanol, requires an ω-specific hydroxylation step using monooxygenase enzymes. An issue with the whole-cell biotransformation of 1-dodecanol using cytochrome P450 monooxygenase (CYP) with ω-specific hydroxylation activity was the low conversion and production of the over-oxidized product of dodecanoic acid. In this study, CYP153A33 from

Indexed as

CYP153A33enzyme engineeringover-oxidationwhole-cell biotransformationα,ω-alkanediol

Identifiers

PMID35059390
PMCPMC8764613
OpenAlexW4206227857

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.