Evidence map›Paper›PMID 35059125›Full record

ArticleACS medicinal chemistry letters2022

Structural Rigidification of

Dorothy Semenya, Meir Touitou, Camila Maringolo Ribeiro, Fernando Rogerio Pavan, Luca Pisano, Vinayak Singh, Kelly Chibale, Georg Bano, Anita Toscani, Fabrizio Manetti and 2 more

Abstract read
In one paragraph

Article in ACS medicinal chemistry letters, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Dorothy SemenyaSchool of Cancer and Pharmaceutical Sciences, King's College London, 150 Stamford Street, London SE1 9NH, United Kingdom.
Meir TouitouSchool of Cancer and Pharmaceutical Sciences, King's College London, 150 Stamford Street, London SE1 9NH, United Kingdom.
Camila Maringolo RibeiroTuberculosis Research Laboratory, School of Pharmaceutical Sciences, Sao Paulo State University (UNESP), Rodovia Araraquara-Jau, km1, 14800-903 Araraquara, Brazil.
Fernando Rogerio PavanTuberculosis Research Laboratory, School of Pharmaceutical Sciences, Sao Paulo State University (UNESP), Rodovia Araraquara-Jau, km1, 14800-903 Araraquara, Brazil.
Luca PisanoSchool of Cancer and Pharmaceutical Sciences, King's College London, 150 Stamford Street, London SE1 9NH, United Kingdom.
Vinayak SinghDrug Discovery and Development Centre (H3D), University of Cape Town, Rondebosch 7701, South Africa.ORCID https://orcid.org/0000-0001-9002-2489
Kelly ChibaleDrug Discovery and Development Centre (H3D), University of Cape Town, Rondebosch 7701, South Africa.ORCID https://orcid.org/0000-0002-1327-4727
Georg BanoSchool of Cancer and Pharmaceutical Sciences, King's College London, 150 Stamford Street, London SE1 9NH, United Kingdom.
Anita ToscaniSchool of Cancer and Pharmaceutical Sciences, King's College London, 150 Stamford Street, London SE1 9NH, United Kingdom.
Fabrizio ManettiDipartimento di Biotecnologie, Chimica e Farmacia, Università di Siena, via Aldo Moro 2, I-53100 Siena, Italy.ORCID https://orcid.org/0000-0002-9598-2339
Beatrice GianibbiDipartimento di Biotecnologie, Chimica e Farmacia, Università di Siena, via Aldo Moro 2, I-53100 Siena, Italy.
Daniele CastagnoloSchool of Cancer and Pharmaceutical Sciences, King's College London, 150 Stamford Street, London SE1 9NH, United Kingdom.ORCID https://orcid.org/0000-0002-7517-5732

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A series of indolyl-3-methyleneamines incorporating lipophilic side chains were designed through a structural rigidification approach and synthesized for investigation as new chemical entities against

Identifiers

PMID35059125
PMCPMC8762742

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.