ArticleClinical epidemiology2022
Incidence, Mortality and Survival in Young People with Co-Occurring Mental Disorders and Substance Use: A Retrospective Linked Routine Data Study in Wales.
Article in Clinical epidemiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 12 citations in OpenAlex.
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- The intergenerational health, social care, and justice system contacts associated with household substance misuse in Wales.International journal of population data science · 2026Article
- Self-harm before and during imprisonment: cohort study of males in prison linking population-based routinely collected data in Wales.BJPsych open · 2025Article
- Substance use disorders, severe mental illness and risk of reoffending among women released from prison: a national cohort study.Scientific reports · 2025Article
- Certified Community Behavioral Health Clinic Services for Clients With Co-occurring Disorders: A Latent Class Approach.Psychiatric services (Washington, D.C.) · 2024Article
- Prevalence, distribution, and inequitable co-occurrence of mental ill-health and substance use among gender and sexuality diverse young people in Australia: epidemiological findings from a population-based cohort study.Social psychiatry and psychiatric epidemiology · 2024Article
- Incidence of SARS-CoV-2 and all-cause mortality in persons with co-occurring substance use disorder and mental illness during the pandemic: a Norwegian cohort study.Social psychiatry and psychiatric epidemiology · 2024Article
- Article
- Health service use of infants involved in family justice care and supervision proceedings in Wales: a data linkage study.International journal of population data science · 2024Article
- Risk Factors Associated With Primary Care-Reported Domestic Violence for Women Involved in Family Law Care Proceedings: Data Linkage Observational Study.Journal of medical Internet research · 2023Observational
- Longitudinal analysis of the relationship between motor and psychiatric symptoms in idiopathic dystonia.European journal of neurology · 2022Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
introductionMental disorder (MD) and substance use (SUD) are associated with poorer than average health and greater mortality. We analysed routine primary care (WLGP) and inpatient admission (PEDW) data to estimate incidence of co-occurring (CC) MD and SUD, and to estimate all-cause mortality and survival with CC, in children and young people in Wales, UK.
methodsA retrospective population-based electronic cohort study using data from the Secure Anonymised Information Linkage (SAIL) Databank. Participants were 958,603 individuals aged 11-25 between 2008 and 2017. We estimated first ever incidence of CC, plotted Kaplan-Meier survival curves and carried out Cox regression to estimate hazard ratios (HR) for risk of death by condition group (CC; MD or SUD only; NC).
resultsHigher incidence of CC in WLGP and PEDW was associated with male sex, older age and greater deprivation. Male to female IRRs (95% CI) were 1.18 (1.12-1.24) in WLGP and 1.17 (1.10-1.24) in PEDW, oldest to youngest IRRs were 24.80 (21.20-29.40) in WLGP and 4.50 (4.08-4.98) in PEDW and most to least deprived IRRs were 3.28 (3.00-3.58) in WLGP and 2.59 (2.36-2.84) in PEDW. Incidence in WLGP significantly decreased between 2008 and 2017 (IRR = 0.88, 95% CI 0.78-0.99); the greatest reduction occurred in the most deprived quintile (IRR 0.67, 95% CI 0.54-0.82). Incidence of hospital admissions remained stable (IRR = 0.95, 95% CI 0.84-1.08). Risk of death was significantly higher for CC compared with NC (HR = 8.7, 95% CI 7.5-10.0).
conclusionMale sex, older age and greater deprivation were associated with higher CC incidence, although the gap between WIMD quintiles has decreased. CC was associated with greater risk of death. Mental health and substance misuse services should be provided in ways that remove barriers, and are acceptable and accessible to all, particularly those at greatest risk, or who are less likely to engage.
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