Evidence map›Paper›PMID 35058692›Full record

ArticleInternational journal of nanomedicine2022

Dynamics of Antimicrobial Peptide Encapsulation in Carbon Nanotubes: The Role of Hydroxylation.

Maryam Zarghami Dehaghani, Farrokh Yousefi, Farzad Seidi, S Mohammad Sajadi, Navid Rabiee, Sajjad Habibzadeh, Amin Esmaeili, Amin Hamed Mashhadzadeh, Christos Spitas, Ebrahim Mostafavi and 1 more

Abstract read
In one paragraph

Article in International journal of nanomedicine, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Maryam Zarghami DehaghaniJiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources and Joint International Research Lab of Lignocellulosic Functional Materials, Nanjing Forestry University, Nanjing, 210037, People's Republic of China.
Farrokh YousefiDepartment of Physics, University of Zanjan, Zanjan, 45195-313, Iran.ORCID 0000-0001-7427-5363
Farzad SeidiJiangsu Co-Innovation Center of Efficient Processing and Utilization of Forest Resources and Joint International Research Lab of Lignocellulosic Functional Materials, Nanjing Forestry University, Nanjing, 210037, People's Republic of China.
S Mohammad SajadiDepartment of Nutrition, Cihan University-Erbil, Erbil, Iraq.
Navid RabieeDepartment of Physics, Sharif University of Technology, Tehran, Iran.ORCID 0000-0002-6945-8541
Sajjad HabibzadehDepartment of Chemical Engineering, Amirkabir University of Technology (Tehran Polytechnic), Tehran, 1591639675, Iran.
Amin EsmaeiliDepartment of Chemical Engineering, School of Engineering Technology and Industrial Trades, College of the North Atlantic - Qatar, Doha, Qatar.
Amin Hamed MashhadzadehMechanical and Aerospace Engineering, School of Engineering and Digital Sciences, Nazarbayev University, Nur-Sultan, 010000, Kazakhstan.ORCID 0000-0001-8146-8198
Christos SpitasMechanical and Aerospace Engineering, School of Engineering and Digital Sciences, Nazarbayev University, Nur-Sultan, 010000, Kazakhstan.
Ebrahim MostafaviStanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA 94305, USA.ORCID 0000-0003-3958-5002
Mohammad Reza SaebDepartment of Polymer Technology, Faculty of Chemistry, Gdańsk University of Technology, Gdańsk, 80-233, Poland.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionCarbon nanotubes (CNTs) have been widely employed as biomolecule carriers, but there is a need for further functionalization to broaden their therapeutic application in aqueous environments. A few reports have unraveled biomolecule-CNT interactions as a measure of response of the nanocarrier to drug-encapsulation dynamics.

methodsHerein, the dynamics of encapsulation of the antimicrobial peptide HA-FD-13 (accession code 2L24) into CNTs and hydroxylated CNTs (HCNTs) is discussed.

resultsThe van der Waals (vdW) interaction energy of CNT-peptide and HCNT-peptide complexes decreased, reaching -110.6 and -176.8 kcal.Mol DISCUSSION: The peptide was encased in the HCNTs comparatively more rapidly, due to the presence of both electrostatic and vdW interactions between the peptide and HCNTs. However, the peptide remained encapsulated throughout the vdW interaction in both systems. The negative values of the free energy of the two systems showed that the encapsulation process had occurred spontaneously. Of note, the lower free energy in the HCNT system suggested more stable peptide encapsulation.

Indexed as

Nanotubes, CarbonAntimicrobial PeptidesHydroxylationMolecular Dynamics SimulationPeptidesAntimicrobial PeptidesNanotubes, CarbonPeptidesantimicrobial peptidecarbon nanotubesdrug deliveryencapsulationhydroxylationmolecular dynamic simulation

Identifiers

PMID35058692
PMCPMC8765279

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.