Evidence map›Paper›PMID 35058638›Full record

ArticleNature2022

Life histories of myeloproliferative neoplasms inferred from phylogenies.

Nicholas Williams, Joe Lee, Emily Mitchell, Luiza Moore, E Joanna Baxter, James Hewinson, Kevin J Dawson, Andrew Menzies, Anna L Godfrey, Anthony R Green and 2 more

Abstract read
PubMed Publisher
In one paragraph

Article in Nature, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 191 papers.

0numbers the graph read from it
0cells of the map it votes in
191citing papers in PubMed
38.9field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

191 citing papers in PubMed, 266 citations in OpenAlex.

  1. Article
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  15. Mathematical modeling ofProceedings of the National Academy of Sciences of the United States of America · 2026
    Article
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  17. Review
  18. Article
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  20. Review

131 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

12 authors at 4 institutions in 1 country.

Nicholas WilliamsWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.ORCID http://orcid.org/0000-0003-3989-9167
Joe LeeWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.
Emily MitchellWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.
Luiza MooreWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.ORCID http://orcid.org/0000-0001-5315-516X
E Joanna BaxterDepartment of Haematology, University of Cambridge, Cambridge, UK.
James HewinsonWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.
Kevin J DawsonWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.
Andrew MenziesWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.
Anna L GodfreyDepartment of Haematology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
Anthony R GreenWellcome-MRC Cambridge Stem Cell Institute, Jeffrey Cheah Biomedical Centre, Cambridge, UK.
Peter J CampbellWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.ORCID http://orcid.org/0000-0002-3921-0510
Jyoti NangaliaWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK. jn5@sanger.ac.uk.ORCID http://orcid.org/0000-0001-7122-4608
Wellcome/MRC Cambridge Stem Cell Institute · GBWellcome Sanger Institute · GBCambridge University Hospitals NHS Foundation Trust · GBUniversity of Cambridge · GB

Funding

Cancer Research UK 23917Medical Research Council MC_PC_17230Wellcome Trust
6 · The paper itself

Abstract

Mutations in cancer-associated genes drive tumour outgrowth, but our knowledge of the timing of driver mutations and subsequent clonal dynamics is limited

Indexed as

MutationMyeloproliferative DisordersNeoplasmsAdultChild, PreschoolClone CellsHumansJanus Kinase 2PhylogenyProtein Phosphatase 2CWhole Genome SequencingJanus Kinase 2PPM1D protein, humanProtein Phosphatase 2C

Identifiers

PMID35058638
OpenAlexW4205211254

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.