SynthesisNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2022
Common and specific large-scale brain changes in major depressive disorder, anxiety disorders, and chronic pain: a transdiagnostic multimodal meta-analysis of structural and functional MRI studies.
Synthesis in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05986513 (Investigating Brain Abnormalities in People With Knee Osteoarthritis Using MRI), which is not on this map. Cited by 66 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Investigating Brain Abnormalities in People With Knee Osteoarthritis Using MRI: a Nociplastic Pain Mechanism Based Assessment
Who cites it
66 citing papers in PubMed, 8 syntheses or guidelines pooled it, 131 citations in OpenAlex.
- Transdiagnostic mapping of common and specific regional homogeneity alterations across affective and psychotic disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026Pooled it
- Shared cortical characteristics in major depressive disorder, anxiety disorder, and chronic pain: a structural MRI meta-analysis study.Translational psychiatry · 2025Pooled it
- Chronic pain in mental disorders: An umbrella review of the prevalence, risk factors, and treatments across 957,168 people with mental disorders and 16,606,910 controls.European psychiatry : the journal of the Association of European Psychiatrists · 2025Pooled it
- Structural brain correlates in major depressive disorder, anxiety disorders, and post-traumatic stress disorder: a diffusion tensor imaging meta-analysis.Psychological medicine · 2025Pooled it
- Brain network properties in chronic pain-a systematic review and meta-analysis of graph-based connectivity metrics.Frontiers in neuroscience · 2025Pooled it
- Structural and functional brain alterations in subthreshold depression: A multimodal coordinate-based meta-analysis.Human brain mapping · 2024Pooled it
- The Dark and Gloomy Brain: Grey Matter Volume Alterations in Major Depressive Disorder-Fine-Grained Meta-Analyses.Depression and anxiety · 2024Pooled it
- A meta-analysis of the neural substrates of monetary reward anticipation and outcome in alcohol use disorder.Human brain mapping · 2023Pooled it
- Can EEG-Neurofeedback Training Enhance Effective Connectivity in People With Chronic Secondary Musculoskeletal Pain? A Secondary Analysis of a Feasibility Randomized Controlled Clinical Trial.Brain and behavior · 2025Trial
- Closed-Loop Infraslow Brain-Computer Interface can Modulate Cortical Activity and Connectivity in Individuals With Chronic Painful Knee Osteoarthritis: A Secondary Analysis of a Randomized Placebo-Controlled Clinical Trial.Clinical EEG and neuroscience · 2025Trial
- Structural alterations in the superior temporal gyrus associated with depressive symptoms in migraine without aura: a voxel-based morphometry and surface-based morphometry magnetic resonance imaging study.Quantitative imaging in medicine and surgery · 2026Article
- Anterior Cingulate Cortex Projections to the Amygdala in Primates: Topographic and Layer-Specific Organization Underlying Emotion and Mood Regulation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Decoding Transdiagnostic Subtypes in Emotional Disorders.CNS neuroscience & therapeutics · 2026Article
- Brain network dynamics reflect psychiatric illness status and transdiagnostic symptom profiles across health and disease.Nature communications · 2026Article
- Associations between retinal morphological features and risk of depression and anxiety disorders.BMC medicine · 2026Article
- Whole-brain mapping of TMS-induced discomfort with large-scale concurrent TMS-fMRI.bioRxiv : the preprint server for biology · 2026Article
- Identifying diagnostic biomarkers in functional motor disorders through multimodal behavioral, neurophysiological, and imaging assessment using explainable machine learning.Journal of neurology · 2026Observational
- Impact of adverse life experiences on pain, depression, anxiety, and comorbidities: a youth longitudinal sample.Pain reports · 2026Article
- Dorsolateral prefrontal cortex hemispheric asymmetry and chronic low back pain at 8-year follow-up in community-dwelling older adults.GeroScience · 2026Article
- Threshold Effect of Anxiety in the Comorbidity of Depression and Chronic Pain: A Cross-Sectional Study Based on Pain Sensitivity.Neuropsychiatric disease and treatment · 2026Article
6 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Major depressive disorder (MDD), anxiety disorders (ANX), and chronic pain (CP) are closely-related disorders with both high degrees of comorbidity among them and shared risk factors. Considering this multi-level overlap, but also the distinct phenotypes of the disorders, we hypothesized both common and disorder-specific changes of large-scale brain systems, which mediate neural mechanisms and impaired behavioral traits, in MDD, ANX, and CP. To identify such common and disorder-specific brain changes, we conducted a transdiagnostic, multimodal meta-analysis of structural and functional MRI-studies investigating changes of gray matter volume (GMV) and intrinsic functional connectivity (iFC) of large-scale intrinsic brain networks across MDD, ANX, and CP. The study was preregistered at PROSPERO (CRD42019119709). 320 studies comprising 10,931 patients and 11,135 healthy controls were included. Across disorders, common changes focused on GMV-decrease in insular and medial-prefrontal cortices, located mainly within the so-called default-mode and salience networks. Disorder-specific changes comprised hyperconnectivity between default-mode and frontoparietal networks and hypoconnectivity between limbic and salience networks in MDD; limbic network hyperconnectivity and GMV-decrease in insular and medial-temporal cortices in ANX; and hypoconnectivity between salience and default-mode networks and GMV-increase in medial temporal lobes in CP. Common changes suggested a neural correlate for comorbidity and possibly shared neuro-behavioral chronification mechanisms. Disorder-specific changes might underlie distinct phenotypes and possibly additional disorder-specific mechanisms.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.