ArticleScientific reports2022
The major plant sphingolipid long chain base phytosphingosine inhibits growth of bacterial and fungal plant pathogens.
Article in Scientific reports, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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15 citing papers in PubMed, 32 citations in OpenAlex.
- Sphingosine synergizes with polymyxin antibiotics againstMicrobiology (Reading, England) · 2026Article
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- Optimization of an Extraction Protocol for Untargeted Metabolomics ofPlants (Basel, Switzerland) · 2026Article
- Phytochemical Profile and Acute Toxicity in CD-1 Mice of the Hydroethanolic Extract and Butanolic Fraction ofJournal of xenobiotics · 2025Article
- Recent Progress in the Diverse Synthetic Approaches to Phytosphingosine.Topics in current chemistry (Cham) · 2025Review
- TheMicrobiology (Reading, England) · 2025Article
- ThebioRxiv : the preprint server for biology · 2024Article
- Streamlined spatial and environmental expression signatures characterize the minimalist duckweedGenome research · 2024Article
- Phytochemical Profiling and Wound Healing Activity ofJournal of experimental pharmacology · 2024Article
- Rapid Discovery of Substances with Anticancer Potential from Marine Fungi Based on a One Strain-Many Compounds Strategy and UPLC-QTOF-MS.Marine drugs · 2023Article
- Sphingolipid Long-Chain Base Signaling in Compatible and Non-Compatible Plant-Pathogen Interactions in Arabidopsis.International journal of molecular sciences · 2023Article
- Perenniality, more than genotypes, shapes biological and chemical rhizosphere composition of perennial wheat lines.Frontiers in plant science · 2023Article
- Article
- Comparative Analysis of Multiple GWAS Results Identifies Metabolic Pathways Associated with Resistance toToxins · 2022Article
- Antifungal Peptide P852 Controls Fusarium Wilt in Faba Bean (Antioxidants (Basel, Switzerland) · 2022Article
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Authors and funding
10 authors at 1 institution in 1 country.
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Abstract
Sphingolipid long chain bases (LCBs) are building blocks of sphingolipids and can serve as signalling molecules, but also have antimicrobial activity and were effective in reducing growth of a range of human pathogens. In plants, LCBs are linked to cell death processes and the regulation of defence reactions against pathogens, but their role in directly influencing growth of plant-interacting microorganisms has received little attention. Therefore, we tested the major plant LCB phytosphingosine in in vitro tests with the plant pathogenic fungi Verticillium longisporum, Fusarium graminearum and Sclerotinia sclerotiorum, the plant symbiotic fungal endophyte Serendipita indica, the bacterial pathogens Pseudomonas syringae pv. tomato (Pst), Agrobacterium tumefaciens, and the related beneficial strain Rhizobium radiobacter. Phytosphingosine inhibited growth of these organisms at micromolar concentrations. Among the fungal pathogens, S. sclerotiorum was the most, and F. graminearum was the least sensitive. 15.9 μg/mL phytosphingosine effectively killed 95% of the three bacterial species. Plant disease symptoms and growth of Pst were also inhibited by phytosphingosine when co-infiltrated into Arabidopsis leaves, with no visible negative effect on host tissue. Taken together, we demonstrate that the plant LCB phytosphingosine inhibits growth of plant-interacting microorganisms. We discuss the potential of elevated LCB levels to enhance plant pathogen resistance.
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