ArticleNature communications2022
Resolving the conflict between antibiotic production and rapid growth by recognition of peptidoglycan of susceptible competitors.
Article in Nature communications, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
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- When, where, and why specialised metabolites are produced: inferring function from expression control.Essays in biochemistry · 2026Review
- Transcriptomic Analysis Reveals the Time-Dependent Mechanism of Antifungal Activity inMicroorganisms · 2026Article
- Assessing the Ecological Roles of Resistomes within Microbial Communities in Antibiotic-contaminated Ecosystems.Microbial ecology · 2026Review
- Regulatory rewiring drives intraspecies competition in Bacillus subtilis.PLoS genetics · 2026Article
- Sugar ABC transporter repertoires predict ecological dynamics in gut microbiome communities.Research square · 2026Article
- Differential coping strategies exerted by biofilm and planktonic cells ofMicrobiology spectrum · 2026Article
- Decoding the rhizosphere microbiome againstFrontiers in microbiomes · 2026Review
- Functional Characterization ofAntibiotics (Basel, Switzerland) · 2026Article
- The interaction between litter input and soil microbial community regulates the intraspecific allelopathic effects ofFrontiers in plant science · 2026Article
- Pre-Colonization of Bacillus siamensis on Ocular Surface Mitigates Fusarium keratitis Through Direct Antifungal Activity and Pre-Activation of NF-κB Pathway.Investigative ophthalmology & visual science · 2025Article
- Automated Platform for the Analysis of Multi-Plate Growth and Reporter Data.Microorganisms · 2025Article
- Turning antagonists into allies: Bacterial-fungal interactions enhance the efficacy of controllingScience advances · 2025Article
- Competition-driven phenotypic plasticity in Iron acquisition and aromatic utilization confers a fitness advantage to Pseudomonas putida in an Iron-limited rhizospheric environment.World journal of microbiology & biotechnology · 2024Article
- The Utilization ofMicroorganisms · 2024Article
- Review
- The roles of calcium signaling and calcium deposition in microbial multicellularity.Trends in microbiology · 2023Review
- Selective inhibition of the amyloid matrix of Escherichia coli biofilms by a bifunctional microbial metabolite.NPJ biofilms and microbiomes · 2023Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Microbial communities employ a variety of complex strategies to compete successfully against competitors sharing their niche, with antibiotic production being a common strategy of aggression. Here, by systematic evaluation of four non-ribosomal peptides/polyketide (NRPs/PKS) antibiotics produced by Bacillus subtilis clade, we revealed that they acted synergistically to effectively eliminate phylogenetically distinct competitors. The production of these antibiotics came with a fitness cost manifested in growth inhibition, rendering their synthesis uneconomical when growing in proximity to a phylogenetically close species, carrying resistance against the same antibiotics. To resolve this conflict and ease the fitness cost, antibiotic production was only induced by the presence of a peptidoglycan cue from a sensitive competitor, a response mediated by the global regulator of cellular competence, ComA. These results experimentally demonstrate a general ecological concept - closely related communities are favoured during competition, due to compatibility in attack and defence mechanisms.
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Registered trials
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