Evidence map›Paper›PMID 35058361›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Understanding the local chemical environment of bioelectrocatalysis.

Esther Edwardes Moore, Samuel J Cobb, Ana Margarida Coito, Ana Rita Oliveira, Inês A C Pereira, Erwin Reisner

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed.

  1. Controlled Acidity Gradients Enable COACS central science · 2026
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  2. Semiartificial COChemical reviews · 2026
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  3. Electroenzymatic COAngewandte Chemie (International ed. in English) · 2026
    Review
  4. Toward Solar-Powered Growth of AutotrophicJournal of the American Chemical Society · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Enzymatic Flow Electrolyzer for COAngewandte Chemie (International ed. in English) · 2025
    Article
  9. Diffusional Voltammetry in Finite Spaces.ACS electrochemistry · 2025
    Review
  10. Semiartificial Photoelectrochemistry for COJournal of the American Chemical Society · 2025
    Article
  11. Solar-Driven Paired COJournal of the American Chemical Society · 2025
    Article
  12. Article
  13. Article
  14. Network of epistatic interactions in an enzyme active site revealed by large-scale deep mutational scanning.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  15. Connecting Biological and Synthetic Approaches for Electrocatalytic COAngewandte Chemie (International ed. in English) · 2024
    Review
  16. Review
  17. Article
  18. Article
  19. Fast CONature chemistry · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Esther Edwardes MooreYusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom.
Samuel J CobbYusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom.ORCID 0000-0001-5015-8090
Ana Margarida CoitoInstituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, 2780-157 Oeiras, Portugal.ORCID 0000-0002-3162-4372
Ana Rita OliveiraInstituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, 2780-157 Oeiras, Portugal.ORCID 0000-0001-7828-4152
Inês A C PereiraInstituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, 2780-157 Oeiras, Portugal.ORCID 0000-0003-3283-4520
Erwin ReisnerYusuf Hamied Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, United Kingdom; reisner@ch.cam.ac.uk.ORCID 0000-0002-7781-1616

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bioelectrochemistry employs an array of high-surface-area meso- and macroporous electrode architectures to increase protein loading and the electrochemical current response. While the local chemical environment has been studied in small-molecule and heterogenous electrocatalysis, conditions in enzyme electrochemistry are still commonly established based on bulk solution assays, without appropriate consideration of the nonequilibrium conditions of the confined electrode space. Here, we apply electrochemical and computational techniques to explore the local environment of fuel-producing oxidoreductases within porous electrode architectures. This improved understanding of the local environment enabled simple manipulation of the electrolyte solution by adjusting the bulk pH and buffer pK

Indexed as

Electrochemical TechniquesElectrochemistryAlgorithmsBuffersElectrodesElectrolytesEnzymesMicroelectrodesMolecular StructurePorosityStructure-Activity RelationshipBuffersElectrolytesEnzymesbioelectrochemistryCO2 reductionenzymeshydrogen evolutionlocal pH

Identifiers

PMID35058361
PMCPMC8795565

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.