ArticleProceedings of the National Academy of Sciences of the United States of America2022
Cell-free DNA profiling informs all major complications of hematopoietic cell transplantation.
Registry-linked trialOpen access · hybridAbstract read
In one paragraph
Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06715046 (Cell Free DNA Profiling As a Tool to Monitor Clinically-Relevant Events in Allogeneic Hematopoietic Stem Cell Transplantation), which is not on this map. Cited by 33 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
33citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 4% of its field
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Cell Free DNA Profiling As a Tool to Monitor Clinically-Relevant Events in Allogeneic Hematopoietic Stem Cell Transplantation
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 44 citations in OpenAlex.
- The Prognostic Value of Circulating Tumor DNA for Clinical Outcomes in Patients Undergoing Hematopoietic Cell Transplantation: A Systematic Review and Meta-Analysis.International journal of molecular sciences · 2026Pooled it
- Article
- Cell-free nucleic acids as a non-invasive biomarker for predicting COVID-19 disease severity and outcome: a retrospective cohort study.BMC infectious diseases · 2026Article
- Advances in graft-versus-host disease: emerging therapeutic strategies, biomarker discoveries, and innovative treatment approaches.Frontiers in immunology · 2026Review
- Pre-transplant microRNA serum profiles and association with acute graft-versus-host disease in allogeneic hematopoietic stem cell transplantation.Frontiers in immunology · 2026Article
- Bridging Discovery and Treatment: Cancer Biomarker.Cancers · 2025Review
- Urine Cell-Free RNA vs Plasma Cell-Free RNA for Monitoring of Kidney Injury and Immune Complications.Clinical chemistry · 2025Article
- Circulating cell-free RNA signatures for the characterization and diagnosis of myalgic encephalomyelitis/chronic fatigue syndrome.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Fragment dispersity index analysis of cfDNA fragments reveals chromatin accessibility and enables early cancer detection.Cell reports methods · 2025Article
- Identification of bacteriophage DNA in human umbilical cord blood.JCI insight · 2025Article
- Circulating cell-free DNA methylation patterns indicate cellular sources of allograft injury after liver transplant.Nature communications · 2025Article
- Kinetics of DNases after hematopoietic stem cell transplant.Blood vessels, thrombosis & hemostasis · 2025Article
- Artificial intelligence and machine learning in cell-free-DNA-based diagnostics.Genome research · 2025Review
- [Improving the application of metagenomic next-generation sequencing for pathogen diagnosis in infections related to hematological diseases].Zhonghua xue ye xue za zhi = Zhonghua xueyexue zazhi · 2024Article
- Plasma cell-free RNA signatures of inflammatory syndromes in children.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Insights into the regulatory role of epigenetics in moyamoya disease: Current advances and future prospectives.Molecular therapy. Nucleic acids · 2024Review
- Technical Advances in Circulating Cell-Free DNA Detection and Analysis for Personalized Medicine in Patients' Care.Biomolecules · 2024Review
- Circulating, cell-free methylated DNA indicates cellular sources of allograft injury after liver transplant.bioRxiv : the preprint server for biology · 2024Article
- Hypobaric hypoxia modulated structural characteristics of circulating cell-free DNA in high-altitude pulmonary edema.American journal of physiology. Lung cellular and molecular physiology · 2024Article
- Chronic graft-versus-host disease detected by tissue-specific cell-free DNA methylation biomarkers.The Journal of clinical investigation · 2024Article
Corrections and comments
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Authors and funding
14 authors at 5 institutions in 1 country.
Alexandre Pellan ChengMeinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14853.
Matthew Pellan ChengDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215.
Conor James LoyDepartment of Molecular Biology and Genetics, Cornell University, Ithaca, NY 14853.ORCID 0000-0001-8816-4293
Joan Sesing LenzMeinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14853.
Kaiwen ChenDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215.
Sami SmallingMeinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14853.
Philip BurnhamDepartment of Bioengineering, University of Pennsylvania, Philadelphia, PA 19104.
Kaitlyn Marie TimblinDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215.
José Luis OrejasDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215.
Emily SilvermanDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215.
Paz PolakDepartment of Oncological Sciences, Icahn School of Medicine at Mount Sinai, New York, NY 10029.
Francisco M MartyDivision of Infectious Disease, Brigham and Women's Hospital, Boston, MA 02215.ORCID 0000-0002-3708-8734
Jerome RitzDepartment of Medical Oncology, Dana-Farber Cancer Institute, Boston, MA 02215.ORCID 0000-0001-5526-4669
Iwijn De VlaminckMeinig School of Biomedical Engineering, Cornell University, Ithaca, NY 14853; vlaminck@cornell.edu.
Brigham and Women's Hospital · USCornell University · USHarvard University · USTisch Hospital · USUniversity of Pennsylvania · US
Funding
Epigenetic Profiling of circulating cell-free DNA for the Monitoring of Graft-Versus-Host Disease after Hematopoietic Cell TransplantationR01AI146165 · NIAID · CORNELL UNIVERSITY · PI DE VLAMINCK, IWIJN, RITZ, JEROME · 2020 to 2024
$3.4MMetagenomic profiling of urinary cell-free DNA to monitor urinary tract infection after kidney transplantationR01AI151059 · NIAID · CORNELL UNIVERSITY · PI DADHANIA, DARSHANA, DE VLAMINCK, IWIJN · 2020 to 2024
$3.4MPrecision monitoring of kidney transplants via single-cell and single-molecule sequencingDP2AI138242 · NIAID · CORNELL UNIVERSITY · PI DE VLAMINCK, IWIJN · 2017 to 2017
$2.3MHost-Pathogen Interactions From Measurements of Urinary Cell Free DNA in Kidney TransplantationR21AI133331 · NIAID · WEILL MEDICAL COLL OF CORNELL UNIV · PI DE VLAMINCK, IWIJN, LEE, JOHN RICHARD · 2017 to 2018
$457kMitochondrial Cell-Free DNA as a Marker of Rejection and Damage-Associated Molecular Pattern in Organ TransplantationR21AI124237 · NIAID · CORNELL UNIVERSITY · PI DE VLAMINCK, IWIJN · 2016 to 2017
$427kNIAID NIH HHS DP2 AI138242NIAID NIH HHS R01 AI146165NIAID NIH HHS R01 AI151059NIAID NIH HHS R21 AI124237NIAID NIH HHS R21 AI133331
Abstract
PubMed holds no abstract for this paper.
Indexed as
Cell-Free Nucleic AcidsDNA FingerprintingBiomarkersDisease ProgressionDNA MethylationGraft vs Host DiseaseHematopoietic Stem Cell TransplantationHumansLiquid BiopsyOrgan SpecificityPostoperative ComplicationsRecurrenceTransplantation, HomologousBiomarkersCell-Free Nucleic Acidscell-free DNAdisease relapsegraft-versus-host diseasehematopoietic cell transplantinfection
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390
Registered trials
NCT06715046ClinicalTrials.gov
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.