Evidence map›Paper›PMID 35058357›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2022

Phagocytosis and self-destruction break down dendrites of

Hui Ji, Maria L Sapar, Ankita Sarkar, Bei Wang, Chun Han

Erratum issuedOpen access · hybridAbstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
5.0field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 34 citations in OpenAlex.

  1. Clonal Analysis inBio-protocol · 2026
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  5. Polyploidy promotes transformation of epithelial cells into nonprofessional phagocytes.Proceedings of the National Academy of Sciences of the United States of America · 2025
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  11. Article
  12. Tissue-specific knockout inbioRxiv : the preprint server for biology · 2023
    Article
  13. Article
  14. TheProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  15. Article
  16. A nerve-wracking buzz: lessons fromFrontiers in aging neuroscience · 2023
    Review
  17. The NADeLife · 2022
    Article
  18. Macrophage depletion blocks congenital SARM1-dependent neuropathy.The Journal of clinical investigation · 2022
    Article
  19. A photo-switchable assay system for dendrite degeneration and repair inProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Hui JiWeill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853.ORCID 0000-0001-5432-8157
Maria L SaparWeill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853.
Ankita SarkarWeill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853.
Bei WangWeill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853.ORCID 0000-0003-3002-3302
Chun HanWeill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853; chun.han@cornell.edu.ORCID 0000-0001-7319-8095
Cornell University · US

Funding

Mechanisms of the recognition of degenerating dendritesR01NS099125 · NINDS · CORNELL UNIVERSITY · PI HAN, CHUN · 2016 to 2020
$2.1M
Broad wavelength range Zeiss 780 NLO/confocal system for the Cornell Imaging CoreS10OD018516 · OD · CORNELL UNIVERSITY · PI ZIPFEL, WARREN R · 2014 to 2014
$834k
A light-inducible protein trapping system for studying cellular dynamics in DrosophilaR21OD023824 · OD · CORNELL UNIVERSITY · PI HAN, CHUN · 2017 to 2018
$414k
NIH HHS R21 OD023824NIH HHS S10 OD018516NINDS NIH HHS R01 NS099125
6 · The paper itself

Abstract

After injury, severed dendrites and axons expose the "eat-me" signal phosphatidylserine (PS) on their surface while they break down. The degeneration of injured axons is controlled by a conserved Wallerian degeneration (WD) pathway, which is thought to activate neurite self-destruction through Sarm-mediated nicotinamide adenine dinucleotide (NAD

Indexed as

PhagocytosisAnimalsDendritesDrosophilaDrosophila ProteinsFluorescent Antibody TechniqueGene Knockdown TechniquesNerve DegenerationNicotinamide-Nucleotide AdenylyltransferasePhosphatidylserinesSensory Receptor CellsWallerian DegenerationDrosophila ProteinsNicotinamide-Nucleotide AdenylyltransferaseNmnat protein, DrosophilaPhosphatidylserinesdendrite degenerationphagocytosisphosphatidylserinePS exposureWallerian degeneration

Identifiers

PMID35058357
PMCPMC8795528
OpenAlexW4205147496

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.