Evidence map›Paper›PMID 35058317›Full record

ArticleGenes & development2022

YTHDC2 control of gametogenesis requires helicase activity but not m

Yuhki Saito, Ben R Hawley, M Rhyan Puno, Shreya N Sarathy, Christopher D Lima, Samie R Jaffrey, Robert B Darnell, Scott Keeney, Devanshi Jain

Open access · diamondAbstract read
In one paragraph

Article in Genes & development, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.

0numbers the graph read from it
0cells of the map it votes in
35citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

35 citing papers in PubMed, 43 citations in OpenAlex.

  1. Article
  2. NMolecular neurobiology · 2026
    Article
  3. Article
  4. Article
  5. Article
  6. Review
  7. Decoding the role of mNeurochemistry international · 2025
    Review
  8. mAdvanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025
    Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. YTHDC2 serves a distinct late role in spermatocytes during germ cell differentiation.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  15. RNA NNature reviews. Urology · 2024
    Review
  16. Article
  17. Article
  18. Review
  19. Review
  20. Gene regulation during meiosis.Trends in genetics : TIG · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Yuhki SaitoLaboratory of Molecular Neuro-oncology, Howard Hughes Medical Institute, Rockefeller University, New York, New York 10065, USA.
Ben R Hawley *Department of Pharmacology, Weill Cornell Medicine, Cornell University, New York, New York 10065, USA.ORCID 0000-0002-2458-7868
M Rhyan Puno *Structural Biology Program, Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.
Shreya N SarathyDepartment of Genetics, Human Genetics Institute of New Jersey, Rutgers University, Piscataway, New Jersey 08854, USA.
Christopher D LimaStructural Biology Program, Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.ORCID 0000-0002-9163-6092
Samie R JaffreyDepartment of Pharmacology, Weill Cornell Medicine, Cornell University, New York, New York 10065, USA.ORCID 0000-0003-3615-6958
Robert B DarnellLaboratory of Molecular Neuro-oncology, Howard Hughes Medical Institute, Rockefeller University, New York, New York 10065, USA.ORCID 0000-0002-5134-8088
Scott KeeneyMolecular Biology Program, Howard Hughes Medical Institute, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA.ORCID 0000-0002-1283-6417
Devanshi JainDepartment of Genetics, Human Genetics Institute of New Jersey, Rutgers University, Piscataway, New Jersey 08854, USA.ORCID 0000-0002-5027-0549
Memorial Sloan Kettering Cancer Center · USCornell University · USHoward Hughes Medical Institute · USRutgers, The State University of New Jersey · US

Funding

X-RAY CRYSTALLOGRAPHYP30CA008748 · NCI · SLOAN-KETTERING INSTITUTE FOR CANCER RES · PI Nicholas D Socci · 1985 to 2026
$347.4M
Combining New Molecular and Informatic Strategies to Find Hidden Ways to Treat Brain DiseaseR35NS097404 · NINDS · ROCKEFELLER UNIVERSITY · PI DARNELL, ROBERT B · 2017 to 2024
$9.0M
Spermatogenic gene regulation and infertilityP50HD104454 · NICHD · CORNELL UNIVERSITY · PI COHEN, PAULA ELAINE · 2021 to 2025
$8.1M
Structural studies of RNA processing and ubiquitin-like protein modificationR35GM118080 · NIGMS · SLOAN-KETTERING INST CAN RESEARCH · PI CHRISTOPHER D. LIMA · 2016 to 2026
$5.0M
Howard Hughes Medical InstituteNCI NIH HHS P30 CA008748NICHD NIH HHS P50 HD104454NIGMS NIH HHS R35 GM118080NINDS NIH HHS R35 NS097404
6 · The paper itself

Abstract

Mechanisms regulating meiotic progression in mammals are poorly understood. The

Indexed as

MeiosisRNA HelicasesAnimalsGene Expression RegulationMaleMammalsMiceRNA, MessengerSpermatogenesisRNA HelicasesRNA, MessengermeiosisN6-methyladenosineRNA-binding proteinsRNA helicasespermatogenesisYthdc2

Identifiers

PMID35058317
PMCPMC8887132
OpenAlexW4206551391

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.